CAS: 16742-51-1; Methyl 2-Hydroxyhexadecanoate

上下游产品

methanol (R)-(-)-2-hydroxyhexadecanoic acid dimethyl sulfate diazomethane(2R)-(+)-1,2-hexadecanediol (R)-(-)-2-hydroxyhexadecanoic acid (S)-2-hydroxyhexadecanoic acid (R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-hexadecanoic acid methyl ester

📜2-溴十六烷酸甲酯置于potassium Acetate,溶剂黄146体系中,化学反应生成2-羟基十六烷酸甲酯
参考文献:Mendel; Coops,Recueil Des Travaux Chimiques Des Pays-Bas,1939,Vol. 58,P. 1141
标题:Mendel; Coops,Recueil Des Travaux Chimiques Des Pays-Bas,1939,Vol. 58,P. 1141

专利信息

专利号:US-5902886-A
优先权日:1997-01-23
标题 :Method for synthesizing oxetan-2-ones and intermediates for their preparation
发明人：SCHICK HANS; WEDLER CHRISTINE
摘要:A method is described for the synthesis of oxetan-2-ones comprising protection of the hydroxy group of an hydroxy ester with an acid-labile acetal protecting group, reduction of this O-protected hydroxy ester to an O-protected hydroxy aldehyde, condensation of this aldehyde with a metal enolate of an activated carboxylic acid derivative and spontaneous deprotection of the hydroxy group during the acidic workup procedure. Using the new O-protected hydroxy aldehydes as intermediates the oxetan-2-ones can be obtained after separation in diastereomerically and enantiomerically pure form, in a remarkably reduced number of steps, and in a significantly improved overall yield.