CAS: 138825-96-4; Methyl 2-Acetamido-5-Bromobenzoate

该化合物是一种溴化芳香酯衍生物,可应用于有机合成和制药研究,化合物的特点是乙酰胺和苯甲酸酯环上的溴替代物,增强其在交叉反应中的回动性,如铃木或Buchwald-Hartwig的相联性.甲基酯组为进一步功能化,包括水解或转基因化提供了多功能处理器.其晶状固体形式确保了在标准实验室条件下处理的稳定性和方便性.这一中间体在生物活性分子合成中特别有用,需要选择性的溴化和薄化功能.高纯度可达到严格的研究和工业标准.

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1241675-38-6 33922-96-2 38985-79-4

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CAS号2719-08-6 N-乙酰邻氨基苯甲酸甲酯

合成工艺路线路线简述

    📜2-乙酰苯甲酸甲酯置于盐酸,溴体系中,化学反应 0.25H,以93%的收率获得2-乙酰胺基-5-溴苯甲酸甲酯
    参考文献:Study Of Alkaloids Of The Siberian And Altai Flora
    标题:Study Of Alkaloids Of The Siberian And Altai Flora
    摘要:合成了含有溴和碘原子的芳香环拉帕克尼丁(lappaconitine)和去乙酰拉帕克尼丁(n-Deacetyllappaconitine)衍生物.这些卤化物与乙基丙烯酸酯或2-甲基-5-乙烯基吡啶进行heck交叉偶联反应,得到了新的 Olefinated拉帕克尼丁衍生物.
    Doi:10.1007/s11172-006-0380-2

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    专利信息


    专利号:US-7122694-B2
    优先权日:1998-11-06
    标 题 :Hydroboronation process
    发明人：MARCUCCIO SEBASTIAN MARIO; RODOPOULOS MARY; WEIGOLD HELMUT
    权利人:BORON MOLECULAR PTY LTD
    摘要:The invention relates to processes for the synthesis of aryl or alkene borates which comprises reacting: (i) an olefinic compound having a halogen or halogen-like substituent in a vinylic substitution position, or (ii) an aromatic ring having a halogen or halogen-like substituent in a ring substitution position, with a disubstituted monohydroborane in the presence of a Group 8-11 metal catalyst. The invention also relates to the use of these borates in coupling reactions. The invention further relates to certain disubstituted monohydroboranes and aryl or alkene borates.

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    主要参考文献

    参考标题:A General And Direct Reductive Amination Of Aldehydes And Ketones With Electron-Deficient Anilines
    作者:Rolf Breinbauer,Jakob Pletz,Bernhard Berg
    摘要:And 14 Ketones. In Our Ongoing Efforts In Preparing Tool Compounds For Investigating And Controlling The Biosynthesis Of Phenazines, We Recognized The Limitations Of Existing Protocols For C-N Bond Formation Of Electron-Deficient Anilines When Using Reductive Amination. After Extensive Optimization, We Have Established Three Robust And Scalable Protocols For The Reductive Amination Of Ketones With Electron-Deficient

    合成参考文献


    参考文献:10.1055/s-0035-1560990
    摘要:Karade N, Kalbandhe A, Kavale A, Thorat P. Oxidative Cleavage of C2–C3 Bond in Isatin Using (Diacetoxyiodo)benzene: A Facile Synthesis of Carbamates of Alkyl Anthranilates. Synlett. 2015 Dec 22;27(05):763–8. doi: 10.1055/s-0035-1560990.
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