CAS: 131864-71-6; (S)-1-(2-Chlorophenyl)Ethanol

相似化合物

13524-04-4 120466-66-2 2142-68-9

上下游产品

1-(2-chlorophenyl)ethanone 2-chlorostyrene vinyl acetate 2'-chloro-sec-phenethyl alcohol 2-propen-1-yl 1-{4-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-[(methyloxy)carbonyl]-2-thienyl}-1H-benzimidazole-5-carboxylate methyl 5-(5-bromo-1H-benzimidazol-1-yl)-3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}thiophene-2-carboxylate 5-(5-bromo-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-chlorophenyl]ethyl}oxy)thiophene-2-carboxamide

1-(2-氯苯基)乙醇置于2-己醇,Geotrichum Candidum Ifo 4597 Cells On Bl-100 Polymer,环己酮体系中,用 正己烷 用作溶剂,化学反应 48.0H,反应生成(S)-1-(2-氯苯基)乙醇
参考文献:Stereoselective Oxidation And Reduction By Immobilized Geotrichum Candidum In An Organic Solvent
标题:Stereoselective Oxidation And Reduction By Immobilized Geotrichum Candidum In An Organic Solvent
摘要:将真菌地霉菌(geotrichum Candidum)的细胞固定在水吸收性聚合物上,并用于在有机溶剂中以环己酮,环戊醇或烷-2-醇作为添加剂进行立体选择性氧化和还原反应.通过立体选择性氧化外消旋1-芳基乙醇,获得了对映体纯的(R)-1-芳基乙醇,而通过对相应的酮进行还原,获得了对映体纯的(S)-1-芳基乙醇,这与自由细胞在水中的还原反应不同,后者仅产生低ee值的(R)-或(S)-1-芳基乙醇.通过测量细胞固定在聚合物周围的有机相和水分相中底物和产物的分布,研究了反应机制.使用氘代化合物来确定添加剂的作用.
Doi:10.1039/a900936A

专利信息

专利号:CN-110129382-B
优先权日:2019-01-23
标题 :Method for catalytic synthesis of chiral ortho-halogenated-alpha-phenylethyl alcohol by carbonyl reductase