CAS: 122665-73-0; (S)-2-(4-((2-Chloroethyl)(2-((Methylsulfonyl)Oxy)Ethyl)Amino)Benzamido)Pentanedioic Acid

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CAS号32677-01-3 L-谷氨酸二叔丁酯盐酸盐 | CAS号88050-23-1 ditert-butyl (2... | CAS号76282-66-1 ditert-butyl (2... | CAS号56-86-0 L-谷氨酸 | CAS号122665-70-7 4-((2-Chloroeth...

📜Di-Tert-Butyl 4-Benzoyl-L-Glutamate置于吡啶,三氟乙酸体系中,化学反应 2.17H,反应生成替拉那韦
参考文献:被羧肽酶g2激活为细胞毒性烷基化剂的新型前药.
标题:被羧肽酶g2激活为细胞毒性烷基化剂的新型前药.
摘要:三种新型前药的合成[4-[双[2-(甲氧基氧基)乙基]氨基]苯甲酰基-L-谷氨酸(7),4-[(2-氯乙基)[2-(甲氧基氧基乙基)]氨基]苯甲酰基这里描述了用作抗癌剂的-L-谷氨酸(8)和4-[双(2-氯乙基)氨基]苯甲酰基-L-谷氨酸(9).每种都是双官能烷基化剂,其中离子化羧基官能团的活化作用通过与谷氨酸残基的酰胺键掩盖.这些相对无活性的前药被设计为通过预先施用与细菌羧肽酶g2(cpg2)偶联的单克隆抗体,在肿瘤部位被活化为它们相应的氮烷基化剂(分别为10,11和12).在cpg2存在的情况下,用每种前药监测两种不同肿瘤细胞系的生存力.
Doi:10.1021/jm00164A034

专利信息

专利号:US-2012282255-A1
优先权日:2011-04-07
标题 :Methods and compositions for the treatment of alcoholism and alcohol dependence
发明人：PLUCINSKI GREG
权利人:PLUCINSKI GREG
摘要:The present invention provides for compositions and methods for treating or preventing addictive and compulsive diseases and disorders, particular alcohol-related diseases and disorders, disclosed herein. The GLP activators of the present invention are effective against various alcohol and drug dependency diseases. In accordance with the invention, the present compositions and methods can be used to intercede upstream or downstream in the signal transduction cascade involved in GLP action to treat various alcohol and drug dependency diseases. In one embodiment, the synthesis or release of endogenous GLP can be stimulated. In another embodiment, the endogenous synthesis or release of another molecule active in the cascade downstream from GLP, (e.g., a molecule produced in response to GLP binding to a receptor), can be stimulated. Accordingly, the methods and compositions of the invention are useful for preventing, treating, diagnosing, or monitoring the progression various alcohol and drug dependency diseases disclosed herein.

专利号:US-6829255-B1
优先权日:1999-07-29
标 题 :CDMA base station transmission device and method
发明人：YANAGI SHUZO
权利人:NEC CORP
摘要:Disclosed is a CDMA base station transmission device having: a first spread multiplex synthesis unit that spreads and multiplexes transmit data of a predetermined number of users to be selected from a plurality of users; and a second spread multiplex synthesis unit that is additionally provided when the number of users increases. The first spread multiplex synthesis unit is provided with a first multiplex synthesis part inside the unit, and the first multiplex synthesis part adds the spread-multiplexed data of the first spread multiplex synthesis unit and the spread-multiplexed data of the second spread multiplex synthesis unit, D/A-converts the added spread-multiplexed data, modulates it into radio frequency band, transmits it through the antenna.