CAS: 116026-93-8; Tert-Butyl (3-Formylpyridin-4-yl)Carbamate

相似化合物

42373-30-8 171178-34-0 280115-84-6

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CAS号98400-69-2 4-(叔丁氧羰基氨基)吡啶 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号7647-01-0 盐酸 | CAS号7732-18-5 水 | CAS号504-24-5 4-氨基吡啶 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号42373-30-8 4-氨基-3-吡啶甲醛 | CAS号280115-84-6 4-((叔丁氧基羰基)氨基)烟酸甲酯 | CAS号197507-55-4 8-溴-1,6-萘啶-2-羧酸 | CAS号197507-59-8 1,6-萘啶-2-羧酸 | CAS号407623-72-7 (3-(羟甲基)吡啶-4-基)...

📜二碳酸二叔丁酯置于叔丁基锂体系中,用 四氢呋喃,正戊烷 用作溶剂,化学反应 2.75H,反应生成N-Boc-4-氨基-3-吡啶甲醛
参考文献:环状amp磷酸二酯酶的抑制剂.3.1,2,3,5-四氢-2-氧代咪唑并[2,1-B]喹唑啉的吡啶基和咪唑基类似物的合成和生物学评估.
标题:环状amp磷酸二酯酶的抑制剂.3.1,2,3,5-四氢-2-氧代咪唑并[2,1-B]喹唑啉的吡啶基和咪唑基类似物的合成和生物学评估.
摘要:与环状amp(camp)磷酸二酯酶(pde)抑制剂lixazinone(rs-82856,1)共同的1,2,3,5-四氢-2-氧杂咪唑并[2,1-B]喹唑啉环系统的结构元件杂交具有其他pde抑制剂强心剂的互补特征的anagrelide(3)促进了标题化合物7A-D,11,12和13A,B的设计和合成.这些化合物的必要特征是在拟议的活性位点模型框架内确定的,用于cgmp(iv型)抑制的camp Pde的高亲和力形式.对这些靶点的评估(无论是体外作为血小板或心脏iv型pde的抑制剂,还是体内作为戊巴比妥麻醉的充血性心力衰竭狗模型中的变力剂),都表明这些结构与母体杂环系统相比具有微不足道的增强活性,并且在所有方面均明显低于1.这种差异归因于不存在1的n-环己基-N-甲基丁酰胺基-4-氧基侧链.有人提出酸性内酰胺型官能团是iv型pde抑制剂变力剂(如4-6和7)所共有的.参照图8-10,模拟了ca
Doi:10.1021/jm00119A014

专利信息

专利号:WO-2008022467-A1
优先权日:2006-08-25
标 题 :2-substituted azain doles and 2 substituted thienopyrroles, their precursors and novel processes for the preparation thereof
发明人：LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
权利人:LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
摘要:The present invention relates generally to processes for the chemical synthesis of azaindole and thienopyrrole compounds, in particular azaindole and thienopyrrole compounds that are substituted at the 2-position of the azaindole or thienopyrrole ring, and optionally at additional locations of the azaindole or thienopyrrole ring such as the 1- and/or 3-position, compounds prepared by such processes, and synthetic precursors of such processes. More particularly, the present invention relates to the preparation of 2- substituted azaindoles from an ortho-gem-dihalovinylaminopyridine or from an ortho- gem-dihalovinylaminopyridine N-oxide compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to the preparation of 2-substituted thienopyrroles from an ortho-gem-dihalovinylthiophene compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to processes for the production of ortho-gem- dihalovinylaminopyridines which are useful as starting materials in the production of 2- substituted azaindoles, and novel compounds prepared by the processes. The present invention also relates to processes for the production of ortho-gem-dihalovinylthiophenes which are useful as starting materials in the production of 2-substituted thienopyrroles, and novel compounds prepared by the processes. Formulae (V) and (VII).