CAS: 108294-53-7; P-Iodoclonidine Hydrochloride

上下游产品

N-(2,6-dichloro-4-iodophenyl)-S-methylisothiourea hydroiodide ethylenediamine (2,6-dichloro-4-iodophenyl)thiourea 1-benzoyl-3-(2,6-dichloro-4-iodophenyl)thiourea[125I]-p-Iod°Clonidine

📜(2,6-Dichloro-4-Iodophenyl)Thiourea 以 甲醇,乙醇 用作溶剂,化学反应 20.0H,反应生成盐酸对碘可乐定
参考文献:Radioiodinated P-Iodoclonidine. A High-Affinity Probe For The .Alpha.2-Adrenergic Receptor
标题:Radioiodinated P-Iodoclonidine. A High-Affinity Probe For The .Alpha.2-Adrenergic Receptor
摘要:The Chemical Synthesis Of 2-[(2,6-Dichloro-4-Iodophenyl)Imino]Imidazolidine (Pic) And Its Radioiodinated Analogue [125I]Pic Is Described. Pic Was Synthesized From 2,6-Dichloroaniline In Five Synthetic Steps. This Agent Displayed A High Affinity For The Alpha 2-Adrenergic Receptor (Ic50 = 1.5 Nm) In Competitive Binding Assays Conducted With Purified Human Platelet Plasma Membrane Fractions. For The Synthesis Of Radioiodinated Pic The Triazene Intermediate 11 Was Synthesized From 2,6-Dichloro-4-Nitroaniline In Five Synthetic Steps. Acid-Catalyzed Decomposition Of 11 With No-Carrier-Added Na125I Afforded High Specific Activity [125I]Pic. In View Of Its High Affinity For The Alpha 2-Adrenergic Receptor,[125I]Pic Is A Potentially Useful Probe For Studies In Adrenergic Pharmacology.
Doi:10.1021/jm00390A021