CAS: 105813-14-7; (3S,4R)-3-((Benzo[d][1,3]Dioxol-5-Yloxy)Methyl)-1-Benzyl-4-(4-Fluorophenyl)Piperidine
- 英文名称(3S,4R)-3-((Benzo[d][1,3]Dioxol-5-Yloxy)Methyl)-1-Benzyl-4-(4-Fluorophenyl)Piperidine
- 中文名称(3S,4R)-3-[(1,3-苯并二氧戊环-5-基氧基)甲基]-1-苄基-4-(4-氟苯基)哌啶
- IUPAC名称(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-1-benzyl-4-(4-fluorophenyl)piperidine
- 其它别名(-)-N-Benzylparoxetine; (3S,4R)-3-[(1,3-Benzodioxol-5-Yloxy)Methyl]-4-(4-Fluorophenyl)-1-(Phenylmethyl)-Piperidine; (3S,4R)-3-[(1,3-Benzodioxol-5-Yloxy)Methyl]-1-Benzyl-4-(4-Fluorophenyl)Piperidine; Paroxetine Ep Impurity C(N-Benzyl Paroxetine); Paroxetine Hydrochloride Ep Impurity C; Paroxetine Hcl Anhydrous Ep Impurity C; Paroxetine Impurity 21(Paroxetine Hcl Anhydrous Ep Impurity C); Paroxetine Hydrochloride Anhydrous Ep Impurity C
- CAS编号105813-14-7
- MFCD编号:MFCD18252333
- FDA UNII编号:MLV7RU9XDD
- 分子式:C26H26FNO3分子量:419.5
- 产品CID: 99068
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
上下游产品
Sesamol Methanesulfonic acid (3S,4R)-1-benzyl-4-(4-fluoro-phenyl)-piperidin-3-ylmethyl ester (3S,4R)-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid methyl ester (3S,4R)-[1-benzyl-4-piperidin-3-yl-4-(4-fluorophenyl)]methanolparoxetine合成工艺路线路线简述
📜[(3S,4R)-1-苄基-4-(4-氟苯基)-3-哌啶基]甲醇置于sodium Hydride,三乙胺体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 14.33H,反应生成(3S,4R)-3-[(1,3-苯并二氧戊环-5-基氧基)甲基]-1-苄基-4-(4-氟苯基)哌啶
参考文献:Stereospecific Construction Of Substituted Piperidines. Synthesis Of (−)-Paroxetine And (+)-Laccarin
标题:Stereospecific Construction Of Substituted Piperidines. Synthesis Of (−)-Paroxetine And (+)-Laccarin
摘要:基于对c(3)取代的1,3-环状氨基磺酸盐的高度立体选择性裂解,对(-)帕罗西汀和(+)拉卡林的短程高效对映选择性合成进行了描述.
Doi:10.1039/b617260A
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主要参考文献
参考标题:Enantioselective Synthesis Of N-Alkylamines Through β-Amino C-H Functionalization Promoted By Cooperative Actions Of B(C6F5)3 And A Chiral Lewis Acid Co-Catalyst作者:Yejin Chang,Min Cao,Jessica Z. Chan,Cunyuan Zhao,Yuankai Wang,Rose Yang,Masayuki Wasa |发布日期:2021.2.10
摘要:Seemingly Competitive Lewis Acids, B(C6F5)3, And A Chiral Mg- Or Sc-Based Complex, Promotes The Highly Enantioselective Union Of N-Alkylamines And α,β-Unsaturated Compounds. An Array Of δ-Amino Carbonyl Compounds Was Synthesized Under Redox-Neutral Conditions By Enantioselective Reaction Of A N-Alkylamine-Derived Enamine And An Electrophile Activated By The Chiral Lewis Acid Co-Catalyst. The Utility
合成参考文献
参考文献:10.1055/s-0036-1589353
摘要:Asymmetric Synthesis of Substituted Glutarimides by Ytterbium Catalysis. Synfacts. 2016 Oct 18;12(11):1154. doi: 10.1055/s-0036-1589353.
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