CAS: 875548-97-3; {2-[4-Fluoro-2-Methoxy-5-(Propan-2-yl)Phenyl]-5-(Trifluoromethyl)Phenyl}Methanol

上下游产品

[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]boronic acid (2-chloro-5-(trifluoromethyl)phenyl)methanol [2-iodo-5-(trifluoromethyl)phenyl]methanol 2-(bromomethyl)-1-iodo-4-(trifluoromethyl)benzene 2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl 2'-(bromomethyl)-4-fluoro-2-methoxy-5-(propan-2-yl)-4'-(trifluoromethyl)biphenyl (+)-(5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one (-)-(5S)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4,4-dimethyl-1,3-oxazolidin-2-one

间三氟甲基苯腈置于[rucl2(Benzene)]2,Potassium Phosphate,Potassium Acetate,N,N-二异丙基乙胺,氯甲酸甲酯,三苯基膦,Calcium Chloride体系中,用 四氢呋喃,N-甲基吡咯烷酮,5,5-Dimethyl-1,3-Cyclohexadiene 作为反应溶剂,化学反应 79.75H,反应生成 4'-氟-2'-甲氧基-5'-异丙基-4-(三氟甲基)-联苯-2-甲醇
参考文献: Synthesis Of Intermediates For Preparing Anacetrapib And Derivatives Thereof[fr] Synthèse D'Intermédiaires Pour Préparer L'Anacetrapib Et Ses Dérivés
标题: Synthesis Of Intermediates For Preparing Anacetrapib And Derivatives Thereof[fr] Synthèse D'Intermédiaires Pour Préparer L'Anacetrapib Et Ses Dérivés
摘要:本发明涉及有机化学领域,更具体地涉及合成中间化合物,这些化合物可用于合成药用活性剂,如阿那曲班或其衍生物.

专利信息

专利号:WO-2013091696-A1
优先权日:2011-12-21
标题 :Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:LEK PHARMACEUTICALS; HUMLJAN JAN; MARAS NENAD
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:EP-2468735-A1
优先权日:2010-12-23
标 题:Synthesis of intermediates for preparing anacetrapib and derivates thereof
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-9212118-B2
优先权日:2010-12-23
标题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:HUMLJAN JAN; MARAS NENAD; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-10300471-B2
优先权日:2013-10-08
标题 :Ruthenium-catalyzed synthesis of biaryl compounds in water
发明人：KOOHANG ALI AIDEN; MEHTA ANITA
权利人:CHICAGO DISCOVERY SOLUTIONS LLC
摘要:Using a [RuCl 2 (arene)] 2 complex and a formate source, a directed ortho C—H insertion and aryl-aryl coupling sequence in water provides biaryl compounds useful in the preparation of biologically active molecules and intermediates. Reactions may be conducted in the ambient atmosphere. Ruthenium catalysts prepared from [RuCl 2 (arene)] 2 and a formate source may be prepared in situ or isolated for later use.

专利号:EP-2655348-A1
优先权日:2010-12-23
标 题 :Synthesis of intermediates for preparing anacetrapib and derivatives thereof

专利号:US-2016263565-A1
优先权日:2013-10-08
标题:Ruthenium-catalyzed synthesis of biaryl compounds in water