CAS: 80875-98-5; H-Oic-Oh

相似化合物

97975-67-2 82717-40-6 108507-42-2

上下游产品

ethyl (2S,3aS,7aS)-°Ctahydro-1H-indole-2-carboxylate hydr°Chloride (S)-indoline-2-carboxylic acid (2S,3aS,7aS)-1-Acetyl-°Ctahydro-indole-2-carboxylic acid tert-butyl ester (2S,3aS,7aS)-1-Benzoyl-°Ctahydro-indole-2-carboxylic acid(2S,3aS,7aS)-1-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-°Ctahydro-indole-2-carboxylic acid (2S,3aS,7aS)-°Ctahydro-1H-indole-2-carboxylic acid phenylmethyl ester 4-methylbenzenesulfonate (2S,3aS,7aS)-1-(benzyloxycarbonyl)°Ctahydro-1H-indole-2-carboxylic acid benzyl (S)-(S)-(S)-perhydroindole-2-carboxylate

吲哚-2-羧酸乙酯置于rh On Carbon 盐酸,Sodium Hydroxide,氢气体系中,用 水,溶剂黄146 作为反应溶剂,化学反应 11.0H,反应生成 (2S,3As,7As)-八氢吲哚-2-羧酸
参考文献:新型有效的含有饱和双环氨基酸的血管紧张素转化酶抑制剂的合成与构效关系.
标题:新型有效的含有饱和双环氨基酸的血管紧张素转化酶抑制剂的合成与构效关系.
摘要:描述了一系列新型的,有效的血管紧张素转化酶(ace)抑制剂的合成,这些抑制剂含有饱和的双环氨基酸代替脯氨酸.八氢吲哚-2-羧酸,八氢异吲哚-1-羧酸和八氢-3-氧代异吲哚-1-羧酸可取代巯基和非巯基ace抑制剂中的脯氨酸,从而在体外和体内均产生与卡托普利和依那普利等效的化合物体内.讨论了构效关系.化合物11A(ci-907,吲哚普利)已进入临床评估阶段.
DOI:10.1021/jm00389A006

专利信息

专利号:US-7323575-B2
优先权日:2003-04-09
标题:Process for the synthesis of (2S)-indoline-2-carboxylic acid
发明人：SOUVIE JEAN-CLAUDE; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB
摘要:Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): n nApplication in the synthesis of perindopril and its pharmaceutically acceptable salts.

专利号:US-7358372-B2
优先权日:2003-07-31
标 题 :Method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
发明人：FUGIER CLAUDE; DUBUFFET THIERRY; LANGLOIS PASCAL
权利人:SERVIER LAB
摘要:Process for the synthesis of perindopril of formula (I): n nand its pharmaceutically acceptable salts.

专利号:US-7368580-B2
优先权日:2003-07-31
标 题:Method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
发明人：FUGIER CLAUDE; DUBUFFET THIERRY; LANGLOIS PASCAL
权利人:SERVIER LAB
摘要:Process for the synthesis of perindopril of formula (I): n nand its pharmaceutically acceptable salts.

专利号:US-4914214-A
优先权日:1987-09-17
标 题:Process for the industrial synthesis of perindopril
发明人：VINCENT MICHEL; BALIARDA JEAN; MARCHAND BERNARD; REMOND GEORGES
权利人:ADIR
摘要:Process for the industrial synthesis of perindopril, in which (2S,3aS,7aS)-2-carboxyperhydroindole is condensed with N-[(S)-1-carbethoxybutyl]-(S)-alanine after protection of the carboxyl group, the product resulting from the condensation being then subjected to deprotection of the carboxyl carried by the heterocyclic ring. n The (2S,3aS,7aS)-2-carboxyperhydroindole and N-[(S)-1-carbethoxybutyl]-(S)-alanine are themselves obtained in excellent conditions from 2-carboxyindole and from L-alanine respectively, both available on an industrial scale.

专利号:US-7157484-B2
优先权日:2003-02-28
标 题 :Method for synthesissing (2s, 3as, 7as)-perhydroindole-2-carboxylic acid and the esters thereof and the use thereof for perindopril synthesis
发明人：DUBUFFET THIERRY; LANGLOIS PASCAL
权利人:SERVIER LAB
摘要:Process for the synthesis of compounds of formula (I): n nwherein R represents hydrogen or a protecting group.n n Application in the synthesis of perindopril and pharmaceutically acceptable salts thereof.

专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.