CAS: 78033-08-6; 8-(Methoxymethyl)-1-Methyl-3-(2-Methylpropyl)-7H-Purine-2,6-Dione

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CAS号54052-67-4 6-amino-3-methy... | CAS号78033-18-8 4,5-二氨基-3-异丁基-1...

合成工艺路线路线简述

  • 合成目标产物 8-Methoxymethyl-3-Isobutyl-1-Methylxanthine 主要起始原料 6-Amino-1-Isobutyl-3-Methyl-5-Nitroso-2,4-Pyrimidinedione
  • (文献来源)合成步骤主要原料 6-Amino-1-Isobutyl-3-Methyl-5-Nitroso-2,4-Pyrimidinedione
📜6-氨基-1-异丁基-3-甲基-5-亚硝基尿嘧啶置于raney-Niw-2 Sodium Hydroxide,氢气体系中,用 甲醇,水 作为反应溶剂,20.0~100.0 °C,709.27 Kpa 条件下,反应 30.0H,反应生成 8-甲氧基甲基-3-异丁酰-1-甲基黄嘌呤
参考文献:New Xanthine Derivatives With Potent And Long Lasting Anti-Bronchoconstrictive Activity
标题:New Xanthine Derivatives With Potent And Long Lasting Anti-Bronchoconstrictive Activity
摘要:
DOI:10.1016/0223-5234(87)90056-0

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✅ COA系统入驻 | 共享模式

主要参考文献


1: Zhao C, Shao N, Bryer N, Chen H, Whitman WB, Vinyard DJ, Liu Y. A minimal SufB2C2 complex functions as a [4Fe-4S] cluster scaffold in methanogenic archaea. Microbiol Spectr. 2025 Nov 4;13(11):e0213425. doi: 10.1128/spectrum.02134-25. Epub 2025 Oct 8.
2: Sądel M, Grzanka L, Swakoń J, Wróbel D, Kusyk S, Bossin L, Bilski P. Optically Stimulated Luminescence Silicone Foils for 2D Dose Mapping in Proton Radiotherapy. Materials (Basel). 2025 Apr 24;18(9):1928. doi: 10.3390/ma18091928.
3: Akinyemi TS, Shao N, Lyu Z, Drake IJ, Liu Y, Whitman WB. Tuning Gene Expression by Phosphate in the Methanogenic Archaeon Methanococcus maripaludis. ACS Synth Biol. 2021 Nov 19;10(11):3028-3039. doi: 10.1021/acssynbio.1c00322. Epub 2021 Oct 19. 202(3):e00654-19. doi: 10.1128/JB.00654-19.

合成参考文献


参考文献:10.1371/journal.pone.0218897
摘要:Miller TW, Amason JD, Garcin ED, Lamy L, Dranchak PK, Macarthur R, Braisted J, Rubin JS, Burgess TL, Farrell CL, Roberts DD, Inglese J. Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. PLoS ONE. 2019 Jul 05;14(7):e0218897. doi: 10.1371/journal.pone.0218897.
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