CAS: 744253-37-0; Ethyl 6-Chloro-2-Methylpyrimidine-4-Carboxylate

英文名称Ethyl 6-Chloro-2-Methylpyrimidine-4-Carboxylate
中文名称6-氯-2-甲基-4-嘧啶甲酸乙酯
IUPAC名称ethyl 6-chloro-2-methylpyrimidine-4-carboxylate
其它别名2-甲基-6-氯嘧啶-4-甲酸乙酯; 4-Pyrimidinecarboxylic Acid, 6-Chloro-2-Methyl-, Ethyl Ester
CAS编号744253-37-0
MFCD编号:MFCD16987970
EINECS号:868-949-0
分子式:C8H9ClN2O2分子量:200.62
产品CID: 1734392
产品分类有机原料→分子砌块→芳杂环类化合物→嘧啶类化合物

相似结构搜索
InChIKey: BYRWXFDWTJXLBT-UHFFFAOYSA-N
InChI=1S/C8H9ClN2O2/c1-3-13-8(12)6-4-7(9)11-5(2)10-6/h4H,3H2,1-2H3
计算化学: 氢键受体数4.0氢键供体数*可旋转键数2.0

相似化合物

1112178-31-0 51940-63-7 933702-42-2

MSDS等安全信息

GHS符号GHS07
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

欧盟法规

C&L通报

上下游产品

CAS号159326-53-1 6-羟基-2-甲基-嘧啶-4-乙酸乙酯 | CAS号10302-94-0 (Z)-2-氯-2-丁烯二酸二乙酯 | CAS号623-91-6 富马酸二乙酯

合成工艺路线路线简述

📜富马酸二乙酯置于sodium Ethanolate,氯,三氯氧磷体系中,用乙醇,二氯甲烷作为反应溶剂,化学反应生成 6-氯-2-甲基嘧啶-4-羧酸乙酯
参考文献:Synthesis Of Benzoylpyrimidines As Antagonists Of The Corticotropin-Releasing Factor-1 Receptor
标题:Synthesis Of Benzoylpyrimidines As Antagonists Of The Corticotropin-Releasing Factor-1 Receptor
摘要:A Series Of Benzoylpyrimidines Derived From The Anilinepyrimidine Crf1 Antagonists Were Synthesized. Several Synthetic Routes Were Developed To Explore The Sar Of This Series Of Compounds. Compounds Such As 8D (K-I = 15 Nm) Exhibited High Binding Affinities At The Human Crf1 Receptor. (C) 2004 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2004.05.072