CAS: 686770-61-6; N-(6-Methylbenzo[d]Thiazol-2-yl)-2-((4-Oxo-3-Phenyl-3,4,6,7-Tetrahydrothieno[3,2-D]Pyrimidin-2-yl)Thio)Acetamide
该化合物是一个小分子抑制器,主要以其在调控 Wnt 信号路径方面的作用而闻名;该化合物的特点是能够抑制甘烃合成酶3 (GSK-3) 的活动,这是这条路径中的一个关键调节器;抑制GSK-3, IWP-2,促进-Catin的稳定性,导致增强Wnt信号;这一属性使IWP-2成为研究的宝贵工具,特别是在与干细胞生物学,发育过程和癌症有关的研究中,Wnt 信号起着关键作用;IWP-2通常用于细胞培养实验,并被证明能够影响细胞扩散和差异;其化学结构包括有助于其抑制活动的具体功能组,尽管此处没有提供详细的结构信息;与任何化学物质一样,在实验室环境中与IWP-2合作时,应当遵守适当的处理和安全协议.
- 英文名称N-(6-Methylbenzo[d]Thiazol-2-yl)-2-((4-Oxo-3-Phenyl-3,4,6,7-Tetrahydrothieno[3,2-D]Pyrimidin-2-yl)Thio)Acetamide
- 中文名称IWP2;N-(6-甲基-2-苯并噻唑基)-2-[(3,4,6,7-四氢-4-氧代-3-苯基噻吩并[3,2d]嘧啶-2-基)硫基]乙酰胺
- IUPAC名称N-(6-methylbenzo[d]thiazol-2-yl)-2-((4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide
- 其它别名IWP 2; N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
- CAS编号686770-61-6
- MFCD编号:MFCD12912418
- 分子式:C22H18N4O2S3
- 分子量:466.61
- 产品CID: 1679508
- 产品分类生物化工 → 抑制剂 → 干细胞及Wnt信号通路(Stem Cells & Wnt)
物理性质
合成工艺路线路线简述
海关参考信息
- 2902300000-甲苯
2912110000-甲醛
2912120000-乙醛
2924199090-其他无环酰胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2022191130-A1
优先权日:2021-03-08
标 题:Method for proliferating cardiomyocytes, method for producing cardiomyocytes, and cardiomyocyte proliferating agent
发明人：YAMASHITA JUN; YOSHIOKA MIKI
权利人:UNIV KYOTO
摘要:Provided are a method for proliferating cardiomyocytes, a method for producing cardiomyocytes, and a cardiomyocyte proliferating agent capable of contributing to cardiac regenerative medicine, that make it possible to induce proliferation of human cardiomyocytes by a drug. The method for proliferating cardiomyocytes, method for producing cardiomyocytes, and cardiomyocyte proliferating agent, including a step for culturing cardiomyocytes in the presence of one or more compounds selected from the group consisting of ALK inhibitors, cytochrome P450 omega hydroxylase inhibitors, and fatty acid synthesis inhibitors
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📌 第三方产品分析报告
主要参考文献
1: Wu L, Zhao JC, Kim J, Jin HJ, Wang CY, Yu J. ERG is a critical regulator of Wnt/LEF1 signaling in prostate cancer. Cancer Res. 2013 Oct 1;73(19):6068-79. doi: 10.1158/0008-5472.CAN-13-0882. Epub 2013 Aug 1.
2: Frewer KA, Sanders AJ, Owen S, Frewer NC, Hargest R, Jiang WG. A role for WISP2 in colorectal cancer cell invasion and motility. Cancer Genomics Proteomics. 2013 Jul-Aug;10(4):187-96. Epub 2013 Mar 14.
4: Naqvi SH, Naqvi SH, Bandukda MY, Naqvi SM. Present status and upcoming prospects of hedgehog pathway inhibitors in small cell lung cancer therapy. Infect Agent Cancer. 2013 May 22;8(1):17. doi: 10.1186/1750-9378-8-17.
合成参考文献
参考文献:10.1124/mol.119.115964
摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
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