CAS: 6529-53-9; 1-(2-Bromoethyl)-4-Chlorobenzene

上下游产品

2-(4-Chlorophenyl)ethanol oxirane (4-chlorphenyl)magnesium bromide methanesulfonic acid-2-(4-chlorophenyl)ethyl ester (4-chlorophenethyl)(methyl)sulfane 4-vinylbenzyl chloride (R)-1-(4-Chloro-phenyl)-4,4-dimethyl-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-pentan-3-ol (S)-1-(4-Chloro-phenyl)-4,4-dimethyl-3-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-pentan-3-ol

对氯苯乙酸置于lithium Aluminium Tetrahydride,三溴化磷体系中,化学反应生成 4-氯苯乙基溴化物
参考文献:减少微生物的立体化学控制.第31部分:在选定的反应条件下通过面包酵母还原2-氧代-4-芳基丁酸烷基酯
标题:减少微生物的立体化学控制.第31部分:在选定的反应条件下通过面包酵母还原2-氧代-4-芳基丁酸烷基酯
摘要:已证明在水-有机溶剂中用苯甲酰氯处理面包酵母是抑制α-羟基酯还原中提供α-羟基酯的(S)-对映异构体的酶的有效方法.该方法对于全细胞系统生产具有高化学产率和高对映体过量的(R)产物是有效的.
DOI:10.1016/s0957-4166(98)00277-8

专利信息

专利号:US-6951932-B2
优先权日:2001-10-25
标 题:Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines
发明人：MOORMAN ALLAN R
权利人:KING PHARMACEUTICALS RES & DEV
摘要:The invention provides new methods for synthesis of 2-aralkyloxyadenosines and 2-alkoxyadenosines. The invention is particularly useful for synthesis of 2-[2-(4-chlorophenyl)ethoxy]adenosine. Preferred methods of the invention include activating a guanosine compound followed by hydrolysis; alkylating the hydrolyzed compound with subsequent animation to provide a 2-aralkyloxyadenosine or a 2-alkoxyadenosine compound.

专利号:WO-2014202765-A1
优先权日:2013-06-21
标题 :Preparation of chiral 1-methyl-2,3,4,5-1h-benzodiazepines via asymmetric reduction of alpha-substituted styrenes
发明人：STAVBER GAJ; GAZIC SMILOVIC IVANA; CLUZEAU JEROME; RICHTER FRANK
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides an asymmetric and economic synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine via novel intermediates applying an asymmetric enzymatic, biomimetic or catalytic reduction. The present invention also provides a novel green asymmetric catalytic reduction adapted for an aqueous medium to be applied in the synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine or novel intermediates.

专利号:US-2003199686-A1
优先权日:2001-10-25
标题:Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines

专利号:CA-2465264-C
优先权日:2001-10-25
标 题 :Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines

专利号:CN-1608076-A
优先权日:2001-10-25
标题 :Synthesis of 2-aralkyloxyadenosine and 2-alkoxyadenosine

专利号:JP-2005511551-A
优先权日:2001-10-25
标题 :Synthesis of 2-aralkoxyadenosine and 2-alkoxyadenosine