CAS: 6320-03-2; 2-Chlorothiophenol

该化合物是一种芳香化合物,其特点是含有硫醇和氯(-Cl)功能组,附于苯环,其分子式为C6H5ClS,其特点是一种硫酚结构,氯原子位于硫醇组中,该化合物一般没有色素,可粉色黄色液体,有强效,不愉快的气味,溶于有机溶剂,但由于其缺水芳香结构,在水中溶性有限.奥克罗诺硫醇因其活性,特别是在核分裂代反应中,氯原子可以被各种核糖替代.该化合物用于有机合成,作为染料,药品和农用化学生产的中间体.此外,它展示了某些生物活动,可能具有化学毒性和安全性,因此具有重要的毒性和安全性.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

o-chloroaniline 1,2-dichloro-benzene ethanethiol 2-chlorophenylsulfonyl chloride trithi°Carbonic acid bis-(2-chloro-phenyl ester) t-(2-chloro-phenylsulfanyl)-acrylic acid3t-(2-chloro-phenylsulfanyl)-acrylic acid 2-(2-chloro-phenylsulfanyl)-5-nitro-benzoic acid (2-chloro-phenylsulfanyl)-acetic acid

合成工艺路线路线简述

  • 合成目标产物 2-Chlorothiophenol 主要起始原料 2-Bromochlorobenzene
  • (文献来源)合成步骤主要原料 2-Bromochlorobenzene
邻二氯苯置于硫化氢,甲烷体系中,化学反应生成 邻氯苯硫酚
参考文献:芳香族チオール化合物の製造方法
标题:芳香族チオール化合物の製造方法
摘要:提供一种在高选择率和高纯度下制备芳香族硫醇化合物的方法.在存在金属硫化物的情况下,通过气相反应化合物(1)和硫化氢,制备芳香族硫醇化合物(2)的方法.(其中,R分别独立表示c1-4烷基,羟基,氨基,氰基,硝基,C1-2烷氧基或卤素原子;n为0-5的整数;x为卤素原子)[选择图]无

海关参考信息

专利信息


专利号:US-6815214-B2
优先权日:2000-12-29
标 题 :Pharmaceutical uses and synthesis of diketopiperazines
发明人:BOYCE JIM P; HOWBERT J JEFFRY; TABONE JOHN C
权利人:CELLTECH R & D INC
摘要:The synthesis of novel diketopiperazines, their use in inhibiting cellular events such as those involving NFK-α, NFK-β and in the treatment of inflammation events, a combinatorial library of diverse diketopiperazines and process for their synthesis as a library and as individual compounds. In particular novel diketopiperazines are disclosed including their synthesis and use in cellular events such as activation of the transcription factor, nuclear factor, TNF-α, TNF-β and also apoptosis.

专利号:WO-9616071-A1
优先权日:1994-11-21
标题:PROCESSES FOR THE SYNTHESIS OF 3'-SUBSTITUTED LEWISx COMPOUNDS
发明人:SRIVASTAVA OM; IPPOLITO ROBERT; SRIVASTAVA GEETA; SZWEDA ROMAN; OHUCHI TOSHIO
权利人:GLYCOMED INC; SRIVASTAVA OM; IPPOLITO ROBERT; SRIVASTAVA GEETA; SZWEDA ROMAN; OHUCHI TOSHIO
摘要:Disclosed are processes for the chemical synthesis of 3'-substituted Lewis-OR compounds where R is an aglycon of at least one carbon atom. One particular compound prepared by the processes of this invention is 8-methoxycarbonyl-octyl-2-acetamido-3-O-( alpha -L-fucopyranosyl)-4-O-[3-O-sulfo- beta -D-galactopyranosyl]-2-deoxy- beta -D-glucopyranoside.

专利号:US-6906046-B2
优先权日:2000-12-22
标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes
发明人:JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY
权利人:CELLTECH R & D INC
摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.

专利号:US-2016318862-A1
优先权日:2013-09-25
标 题:Synthesis of delta 12-pgj3 and related compounds
发明人:NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.

专利号:US-6894189-B2
优先权日:2001-04-13
标 题 :Methods of preparing didesmethylsibutramine and other sibutramine derivatives
发明人:SENANAYAKE CHRIS HUGH; HAN ZHENGXU; KRISHNAMURTHY DHILEEPKUMAR; PFLUM DEREK
权利人:SEPRACOR INC
摘要:This invention encompasses novel methods of preparing sibutramine and sibutramine derivatives, and stereomerically pure sibutramine derivatives in particular. Examples of sibutramine derivatives include, but are not limited to, sibutramine metabolites such as desmethylsibutramine and didesmethylsibutramine. The invention further encompasses novel compounds useful in the synthesis of sibutramine derivatives.

专利号:US-7151112-B1
优先权日:2001-09-04
标题:Pharmaceutical uses and synthesis of nicotinamides
发明人:CUTSHALL NEIL S; JEFFREY SCOTT C
权利人:UCB SA
摘要:This invention is directed to methods of using a compound of the formula n nand pharmaceutically acceptable salts thereof, wherein n, X, R 1 and R 2 are disclosed herein, for treating inflammatory events in an animal subject.
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✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Copper-Mediated Direct Sulfenylation Of 4-Hydroxyquinolinones And 4-Hydroxypyridones With Aryl Thiols Via A C−h Functionalization Process
作者:Tao Guo,Hongyan Wang |发布日期:2017.9
摘要:An Efficient Approach For The Direct Sulfanylation Of 4-Hydroxyquinolinones And 4-Hydroxypyridones With Aryl Thiols In The Presence Of Cui/dmso Has Been Developed. The Substrate Scope Is Broad, Allowing Facile Synthesis Of A Range Of Structurally Diverse 3-Sulfanyl-4-Hydroxyquinolinones And 3-Sulfanyl-4-Hydroxypyridones In Good Efficiency.

合成参考文献


摘要:Schatz, J.; Seßler, M., Science of Synthesis Knowledge Updates, (2010) 1, 95.
摘要:Yoshikai, N.; Rayner, C. M.; Graham, M. A., Science of Synthesis Knowledge Updates, (2020) 2, 74.
摘要:Ayad, T.; Pirat, J.-L.; Virieux, D., Science of Synthesis Knowledge Updates, (2022) 1, 321.
摘要:Sinha, A. K.; Singh, R., Science of Synthesis, (2021) , 527.
摘要:Sinha, A. K.; Singh, R., Science of Synthesis, (2021) , 519.
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