CAS: 578-57-4; 1-Bromo-2-Methoxybenzene

上下游产品

CAS号90-04-0 邻氨基苯甲醚 | CAS号5720-06-9 2-甲氧基苯基硼酸 | CAS号95-56-7 2-溴苯酚 | CAS号74-88-4 碘甲烷 | CAS号77-78-1 硫酸二甲酯 | CAS号616-38-6 碳酸二甲酯 | CAS号100-66-3 苯甲醚 | CAS号21702-84-1 2,4-二溴苯甲醚 | CAS号60333-75-7 1-Bromo-2-(2-pr... | CAS号108989-36-2 3,3'-二溴-4,4'-二甲氧基联苯 | CAS号108343-90-4 2-氨基-2-(2-甲氧苯基)乙醇 | CAS号109664-02-0 新隐丹参酮 | CAS号106166-21-6 1-(2-methoxyphe... | CAS号606-45-1 2-甲氧基苯甲酸甲酯 | CAS号579-75-9 邻甲氧基苯甲酸 | CAS号3698-28-0 2-烯丙基苯甲醚 | CAS号10577-44-3 (E/Z)-1-methoxy... | CAS号36802-41-2 双(2-甲氧基)苯基膦 | CAS号40877-17-6 4-chloro-1-(2-m...

邻甲氧基苯胺置于氢溴酸,Sodium Nitrite,溴体系中,用 水 作为反应溶剂,以80%的收率获得产物2-溴苯甲醚
参考文献:使用分子溴轻松,无金属合成芳基溴-桑德迈尔反应的替代方案
标题:使用分子溴轻松,无金属合成芳基溴-桑德迈尔反应的替代方案
摘要:描述了使用分子溴从苯胺衍生物有效无金属合成芳基溴.这种一锅反应可以从相应的富电子苯胺中以中等至优异的产率提供芳基溴,而无需分离重氮盐.该转化反应时间短,环境温度低,后处理简单且对湿气和空气不敏感.这种合成策略代表了经典桑德迈尔反应的另一种方法. 图形概要 无金属桑德迈尔反应策略已用于合成各种芳基溴化物.使用亚硝酸钠和 48% Hbr 水溶液对芳基胺进行重氮化,随后用液溴处理反应物料,得到各种芳基溴化物.研发了大约 12 种不同的芳基胺.从富电子芳基胺中获得了优异的产率.
DOI:10.1007/s12039-023-02228-4

专利信息

专利号:US-10053406-B2
优先权日:2015-10-23
标题 :Synthesis of honokiol
发明人：JARACZ STANISLAV; KOZLOWSKI MARISA; EUN LEE YOUNG; KIM SUN MIN
权利人:COLGATE PALMOLIVE CO; UNIV PENNSYLVANIA
摘要:Disclosed herein are improved methods for the synthesis of honokiol, as well as methods for the synthesis of 3,3′-di-tert-butyl-5,5′-dimethyl-[1,1′-biphenyl]-2,4′-diol, 3′,5-dimethyl-[1,1′-biphenyl]-2,4′-diol, and 2,4′-dimethoxy-3′,5-dimethyl-1,1′-biphenyl, 3,3′,5,5′-tetra-tert-butyl-[1,1′-biphenyl]-2,4′-diol, and certain tetrasubstituted bisphenols, and uses therefor.

专利号:US-7355036-B2
优先权日:2001-07-03
标 题 :Two-stage protective groups for the synthesis of biopolymers
发明人：GUEIMIL RAMON; SCHEFFLER MATTHIAS; STAEHLER PEER F; BEIJER BARBRO
权利人:FEBIT AG
摘要:The invention relates to a method for the synthesis of a nucleic acid by gradual breakdown from protected synthesis building blocks carrying two-stage protective groups. The two-stage protective groups are split by means of a first exposure step and a subsequent chemical treatment step

专利号:US-9212118-B2
优先权日:2010-12-23
标题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:HUMLJAN JAN; MARAS NENAD; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:WO-9429243-A1
优先权日:1993-06-11
标 题 :Synthesis of substituted triphenylenes, useful as discotic liquid crystals
发明人：BUSHBY RICHARD JAMES; CAMMINDGE ANDREW NEIL; HEADDOCK GARETH; BORNER RUTH CAROL; BODEN NEVILLE
权利人:BRITISH TECH GROUP; BUSHBY RICHARD JAMES; CAMMINDGE ANDREW NEIL; HEADDOCK GARETH; BORNER RUTH CAROL; BODEN NEVILLE
摘要:Unsymmetrically substituted triphenylenes required in the synthesis of polymeric discotic liquid crystals are made using iron (III) chloride in organic solvent at room temperature to effect the oxidative coupling of 1,2-dialkoxybenzenes to 3,3',4,4'-tetraalkoxybiphenyls. This is followed by a reductive workup. The same oxidation-reduction protocol also proves effective in the trimerisation of 1,2-dialkoxybenzenes.

专利号:US-4985567-A
优先权日:1988-03-07
标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
发明人：ACHIWA KAZUO; TAKEDA HIDEO
权利人:KAZUO ACHIWA; FUJI YAKUHIN KOGYO KK
摘要:New chiral phosphinopyrrolidine compounds of the general formula: ##STR1## wherein R 1 is hydrogen or --COA 1 , --COOA 2 , --CONHA 3 , --SO 2 A 4 or --PO(A 5 ) 2 , A 1 , A 2 , A 3 , A 4 and A 5 each represents independently alkyl or aryl, R 2 is phenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, and R 3 is phenyl, lower-alkylphenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, with the proviso that R 2 and R 3 may not simultaneously by phenyl, p-di(lower-alkyl)-aminophenyl or p-lower-alkoxyphenyl, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

专利号:US-2001041803-A1
优先权日:2000-03-21
标题 :Conversion of 9-dihydro-13-acetylbaccatin III to baccatin III and 10-deacetyl baccatin III
发明人：KASITU GERTRUDE C; NOAH JAPHETH W
摘要:Novel methods and synthetic intermediates to prepare baccatin III and 10-deacetylbaccatin from readily available 9-dihydro-13-acetylbaccatin III are described. Selective protection and deprotection of the C-7 hydroxyl functionality provides an entry into facile synthesis of novel taxol intermediates, as well as, providing new methods for the preparation of paclitaxel and docetaxel in large scale. Selective oxidation of the C-9 hydroxyl without the need for protection of the C-7 hydroxyl is described.