CAS: 56741-94-7; 2-Amino-6-Phenylpyrimidin-4(3H)-One

该化合物是属于火米地人家族的有机化合物,其特点是六人组成的芳香环,含有1号阵地和3号阵地的两个氮原子. 该化合物具有2号位置的氨基组(-NH2),4号位置的氢氧基组(-OH)和6号位置的苯基组(C6H5),它一般是晶体固体,由于存在氢氧和氨基质组,在极地溶剂中可溶解,可从事氢结合.该化合物的特性表明它在各个领域都具有兴趣,包括制药和生物化学学,因为它可作为合成更复杂的分子或作为潜在治疗剂的建筑块.其反应受各种功能组的影响,允许各种化学变异.应当作为任何化学物质,观测安全和处理预防措施,以减轻潜在危害.

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99844-02-7 915070-01-8 86799-26-0

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上下游产品

guanidinium thi°Cyanate ethyl 3-oxo-3-phenylpropionate diguanidine carbonate guanidine nitrate pyrimidine4,6-dioxo-8-phenyl-2,3,4,6-tetrahydro-1H-pyrimido1,2-apyrimidine 2-amino-3-methyl-6-phenyl-4(3H)-pyrimidinoene 2-amino-5-chloro-6-phenylpyrimidin-4(3H)-one 2-amino-5-iodo-6-phenylpyrimidin-4(3H)-one

合成工艺路线路线简述

    📜苯甲酰乙酸乙酯置于盐酸,水体系中,用 乙醇,甲苯 作为反应溶剂,化学反应 1.0H,以86%的收率获得产物2-氨基-4-羟基-6-苯基嘧啶
    参考文献: 4-Aminopyrimidine Derivatives For Treatment Of Hyperproliferative Disorders[fr] Derives De Pyrimidine Dans Le Traitement De Troubles Hyperproliferatifs
    标题: 4-Aminopyrimidine Derivatives For Treatment Of Hyperproliferative Disorders[fr] Derives De Pyrimidine Dans Le Traitement De Troubles Hyperproliferatifs

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    专利信息


    专利号:WO-8604583-A1
    优先权日:1985-02-05
    标 题 :4-substituted-6-aryl pyrimidine compounds
    发明人：SKULNICK HARVEY I; WIERENGA WENDELL
    权利人:UPJOHN CO
    摘要:Synthesis and anti-neoplastic use of 4-aziridyl-5-substituted/unsubstituted 6-aryl-pyrimidine compounds of formula (IA) as well as N'- AD2-(1-aziridyl)ethyl BD-6-aryl-2,4-pyrimidinediamines of formula (IB) and 4-chloro or bromo-5-substituted/unsubstituted -6-aryl-pyrimidines.

    专利号:US-4795812-A
    优先权日:1985-02-05
    标题:4-substituted-6-aryl-pyrimidine compounds
    发明人：WIERENGA WENDELL; SKULNICK HARVEY I
    权利人:UPJOHN CO
    摘要:PCT No. PCT/US86/00074 Sec. 371 Date Sep. 22, 1986 Sec. 102(e) Date Sep. 22, 1986 PCT Filed Jan. 23, 1986 PCT Pub. No. WO86/04583 PCT Pub. Date Aug. 14, 1986.This invention describes the synthesis and anti-neoplastic use of 4-aziridyl-5-substituted/unsubstituted 6-aryl-pyrimidine compounds of Formula IA IA as well as N'-[2-(1-aziridyl)ethyl]-6-aryl-2,4-pyrimidinediamines of Formula IB IB and 4-chloro or bromo-5-substituted/unstubstituted-6-aryl-pyrimidines.

    专利号:CN-114716961-B
    优先权日:2022-05-04
    标题:A kind of self-complementary quadruple hydrogen bond supramolecular hot melt adhesive and its synthesis method

    专利号:CN-114716961-A
    优先权日:2022-05-04
    标 题 :A kind of self-complementary quadruple hydrogen bond supramolecular hot melt adhesive and its synthesis method

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    合成参考文献


    参考文献:10.1016/j.bmcl.2016.01.009
    摘要:Mesleh MF, Cross JB, Zhang J, Kahmann J, Andersen OA, Barker J, Cheng RK, Felicetti B, Wood M, Hadfield AT, Scheich C, Moy TI, Yang Q, Shotwell J, Nguyen K, Lippa B, Dolle R, Ryan MD. Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB. Bioorganic & Medicinal Chemistry Letters. 2016 Feb;26(4):1314–8. doi: 10.1016/j.bmcl.2016.01.009.
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