专利号:US-4400550-A 优先权日:1982-02-12 标题 :Synthesis of the navel orange worm pheromone (Z,Z)-11,13-hexadecadienal 发明人:BISHOP CLYDE E; MORROW GARY W 权利人:ALBANY INT CORP 摘要:A process for the synthesis of (Z,Z)-11-13-hexadecadienal is disclosed, starting with undecylenic alcohol.
专利号:US-2003157592-A1 优先权日:1999-12-16 标题:Moss genes from physcomitrella patens encoding proteins involved in the synthesis of tocopherols and carotenoids 发明人:LERCHL JENS; RENZ ANDREAS; EHRHARDT THOMAS; REINDL ANDREAS; CIRPUS PETRA; BISCHOFF FRIEDRICH; FRANK MARKUS; FREUND ANNETTE; DUWENIG ELKE; SCHMIDT RALF-MICHAEL; RESKI RALF; BADUR RALF 摘要:Isolated nucleic acid molecules, designated TCMRP nucleic acid molecules, which encode novel TCMRPs from e.g. Phycomitrella patens are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TCMRP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated TCMRPs, mutated TCMRPs, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from transformed cells, organisms or plants based on genetic engineering of TCMRP genes in these organisms.
专利号:US-12234495-B2 优先权日:2021-04-06 标 题:Synthesis of beta-hydroxyisovalerate and methods of use 发明人:VEMURI GOUTHAM; LINDSAY CHRISTOPHER; ROBERG-PEREZ KEVIN; SNOW CHRISTOPHER D; CAMERON ELIZABETH A 权利人:SASYA INC 摘要:The biological production of beta-hydroxyisovalerate (βHIV) using at least one non-natural enzyme. The non-natural enzyme for the biologically-derived βHIV provides more beta-hydroxyisovalerate synthase activity than the wild-type parent. The non-natural enzyme having one or more modifications of substrate-specificity positions. The non-natural enzyme can be expressed in a microorganism, such as a yeast or bacteria, wherein the microorganism comprises an active βHIV metabolic pathway for the production of βHIV. Alternatively, the non-natural enzyme can be a βHIV synthase used to produce βHIV in a cell-free environment. The biological derivation of βHIV eliminates toxic by-products and impurities that result from the chemical production of βHIV, such that βHIV produced by a non-natural enzyme prior to any isolation or purification process has not been in substantial contact with any halogen-containing component.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-9453037-B2 优先权日:2011-07-28 标 题 :Methylphenidate-prodrugs, processes of making and using the same 发明人:GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB 权利人:KEMPHARM INC; KEMPHARM INC 摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.
专利号:US-7906710-B2 优先权日:2001-01-05 标 题:Transgenic plants containing altered levels of steroid compounds 发明人:KARUNANANDAA BALASULOJINI; POST-BEITTENMILLER MARTHA; VENKATRAMESH MYLAVARAPU; KISHORE GANESH M; THORNE GREGORY M; LEDEAUX JOHN R 权利人:MONSANTO CO 摘要:Disclosed are constructs comprising sequences encoding 3-hydroxy-3methylglutaryl-Coenzyme A reductase and at least one other sterol synthesis pathway enzyme. Also disclosed are methods for using such constructs to alter sterol production and content in cells, plants, seeds and storage organs of plants. Also provided are oils and compositions containing altered sterol levels produced by use of the disclosed constructs. Novel nucleotide sequences useful in the alteration of sterol production are also provided. Also provided are cells, plants, seeds and storage organs of plants comprising sequences encoding 3-hydroxy-3methylglutaryl-Coenzyme A reductase, at least one other sterol synthesis pathway enzyme and at least one tocopherol synthesis enzyme.
1: Selvakumar D, Sian K, Sugito S, Singh T. Ochronosis of the aortic valve. J Thorac Dis. 2018 May;10(5):E332-E334. doi: 10.21037/jtd.2018.05.16. 2: Medina ME, Galano A, Trigos A. On the Scavenging Ability of Homogentisic Acid and Ergosterol towards Free Radicals Derived from Ethanol Consumption. J Phys Chem B. 2018 Jul 9. doi: 10.1021/acs.jpcb.8b04619. [Epub ahead of print]
合成参考文献
参考文献:10.1136/jcp.2009.071365 摘要:Taylor AM, Wilson PJ, Ingrams DR, Helliwell TR, Gallagher JA, Ranganath LR. Calculi and intracellular ochronosis in the submandibular tissues from a patient with alkaptonuria. J Clin Pathol. 2010 Feb;63(2):186–8. doi: 10.1136/jcp.2009.071365. 参考文献:10.1007/s10545-011-9374-9 摘要:Ranganath LR, Cox TF. Natural history of alkaptonuria revisited: analyses based on scoring systems. J Inherit Metab Dis. 2011 Dec;34(6):1141–51. doi: 10.1007/s10545-011-9374-9. 参考文献:10.4103/0970-9185.81839 摘要:Pandey R, Kumar A, Garg R, Khanna P, Darlong V. Perioperative management of patient with alkaptonuria and associated multiple comorbidities. J Anaesthesiol Clin Pharmacol. 2011 Apr;27(2):259–61.