CAS: 2506-41-4; 2-(Chloromethyl)Naphthalene

上下游产品

N-chloro-succinimide 2-Methylnaphthalene 2-Naphthalenemethanol naphthalene 1-(β-naphthylmethyl)piperazine 1,4-bis-[2]naphthylmethyl-piperazine 2-naphthyl-2-ylmethyl-bis(2-chloroethyl)amine hydr°Chloride 3,5-dichloro-2-[2]naphthylmethoxy-benzoic acid

2-甲基萘置于n-羟基邻苯二甲酰亚胺,四溴化碳,三氯异氰尿酸,Copper(II) Acetate Monohydrate体系中,用 二氯甲烷 用作溶剂,化学反应 21.0H,以7%的收率获得2-(氯甲基)萘
参考文献:使用三氯异氰尿酸的轻度脂族和苯甲烃ch键式氯化反应
标题:使用三氯异氰尿酸的轻度脂族和苯甲烃ch键式氯化反应
摘要:我们介绍了使用n-羟基邻苯二甲酰亚胺(nhpi)作为自由基引发剂和可商购的三氯异氰尿酸(tcca)作为氯源,在25-30oc下仅1当量的底物对脂族和苄基烃的受控单氯化反应.催化量的cbr 4由于形成链状.cbr 3而大大减少了反应时间部首.苯甲酰ch氯化可为带有吸电子(50-85%)或弱供电子基团(31-73%)的芳烃提供中等至非常好的收率.环状脂族底物收率低(24-38%).产物可以克量级合成,然后通过蒸馏简单纯化.我们报告了3-甲基苯甲酸酯的第一次直接侧链氯化,得到3-(氯甲基)苯甲酸甲酯,这是合成血管扩张剂taprostene的重要组成部分.
Doi:10.1021/acs.Joc.6B02829

专利信息

专利号:US-11976052-B2
优先权日:2019-01-11
标题:Leukotriene synthesis inhibitors
发明人：BURGOYNE DAVID L; DEBRUIN ERIN; FONAREV JULIA; YEE JAMES GEE KEN; LANGLANDS JOHN MICHAEL
权利人:NAEGIS PHARMACEUTICALS INC
摘要:Provided are specific leukotriene synthesis inhibitor compounds and pharmaceutical compositions comprising the compounds and methods of using the compounds and the pharmaceutical compositions in treating, for example, inflammatory diseases or conditions.

专利号:US-5298512-A
优先权日:1989-04-07
标 题:Substituted chromans and their use in the treatment of asthma, arthritis and related diseases
发明人：EGGLER JAMES F; MARFAT ANTHONY; MASAMUNE HIROKO; MELVIN JR LAWRENCE S
权利人:PFIZER
摘要:Substituted chromans which by inhibiting 5-lipoxygenase enzyme are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction, stroke and related disease states in mammals, pharmaceutical compositions thereof, a method of treatment therewith, and to intermediates useful in the synthesis thereof.

专利号:RU-2194044-C2
优先权日:1997-10-01
标 题 :Derivatives of benzamidine, method of their synthesis and pharmaceutical composition

专利号:CN-119350120-A
优先权日:2024-09-02
标题 :Synthesis method of 1, 4-dichloro methylnaphthalene

专利号:US-5919797-A
优先权日:1996-04-24
标题:Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites
发明人：GOODMAN MARK M; FARAJ BAHJAT
权利人:UNIV EMORY
摘要:Halogenated naphthyl methoxy piperidines having a strong affinity for the serotonin transporter are disclosed. Those compounds can be labeled with positron-emitting and/or gamma emitting halogen isotopes by a late step synthesis that maximizes the useable lifeterm of the label. The labeled compounds are useful for localizing serotonin transporter sites by positron emission tomography and/or single photon emission computed tomography.

专利号:CN-117843824-A
优先权日:2024-01-08
标题 :Synthesis method of achyranthes bidentata polysaccharide ABW90-1 and/or ABW50-1