专利号:US-4913852-A 优先权日:1986-06-24 标题 :Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with pregnane derivatives 发明人:MILIONI CATHERINE; EFTHYIMIOPOULOS CONSTANTIN; KOCH BERNARD; JUNG LOUIS; JUNG JEAN 权利人:MILIONI CATHERINE; EFTHYIMIOPOULOS CONSTANTIN; KOCH BERNARD; JUNG LOUIS; JUNG JEAN 摘要:Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with derivatives of Δ-4-pregnene-3,20-dione or with derivatives of Δ-1,4-pregnadiene-3,20-dione of the general formulas (I), (II) and (III), having glucocorticoidal and anti-inflammatory properties have been prepared and tested. Pharmaceutical compositions, medicaments containing them as well as their applications are claimed, particularly in the cutaneous and ophthalmic fields. ##STR1##
专利号:US-2018194804-A1 优先权日:2015-07-09 标 题:Simplified and scalable method for synthesis of 2,6-bis(methionyl)- 1,4-diketopiperazine
专利号:US-3721662-A 优先权日:1967-02-04 标题:Method for producing an active carboxylic acid ester 发明人:FUJINO M; HTANAKA C 权利人:TAKEDA CHEMICAL INDUSTRIES LTD 摘要:AN ACTIVE CARBOXYLIC ACID ESTER OF THE FORMULA 1-(R-COO-),2,3,4,5,6-(CL)5-BENZENE USEFUL IN THE SYNTHESIS OF PEPTIDE, IS PREPARED BY REACTING FORMIC ACID, CERTAIN HYDROCARBON-CARBOXYLIC ACIDS, N-PROTECTED AMINO ACIDS OR A PEPTIDE WITH PROTECTED TERMINAL AMINO GROUP WITH PENTACHLOROPHENYL DICHLOROACETATE OR PENTACHLOROPHENYL TRICHLOROACETATE, IN THE PRESENCE OF A TERTIARY AMINE OR DICYCLOHEXYLAINE.
专利号:US-9695119-B2 优先权日:2008-08-01 标题:Methionine analogs and methods of using same 发明人:BASSIRI MANSOUR; RAHIMI-LARIJANI AFSANEH 权利人:BIOXINESS PHARMACEUTICALS INC 摘要:Provided are methionine analogs which may be useful for inhibiting protein synthesis, inhibiting microbial growth and/or treating infectious diseases. In some instances, the analogs exhibit bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and/or antiviral properties. Also provided are methods of treatment and methods of preparation, as well as kits and unit dosages.
专利号:US-5316935-A 优先权日:1992-04-06 标题 :Subtilisin variants suitable for hydrolysis and synthesis in organic media 发明人:ARNOLD FRANCES H; CHEN KEQIN 权利人:CALIFORNIA INST OF TECHN 摘要:In accordance with the present invention, there are provided novel, modified subtilisin enzyme(s) having improved catalytic activity and/or stability in organic media.
专利号:CN-107922355-B 优先权日:2015-07-09 标 题:Simplified and scalable process for the synthesis of 2, 6-bis (methionyl) -1, 4-diketopiperazines