CAS: 207981-44-0; 1-(2,5-Difluorophenyl)Thiourea

上下游产品

2,5-difluoroaniline 6-amino-1-(2,5-difluorophenyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one 5,6-diamino-1-(2,5-difluorophenyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

📜2,5-二氟苯胺置于水,Sodium Hydroxide体系中,用 甲醇,丙酮 用作溶剂,化学反应生成2,5-二氟苯基硫脲
参考文献:高通量筛选重组热激蛋白70(hsp70)复合物中蛋白质-蛋白质相互作用的抑制剂.
标题:高通量筛选重组热激蛋白70(hsp70)复合物中蛋白质-蛋白质相互作用的抑制剂.
摘要:蛋白质间相互作用(ppi)是推定药物靶标的重要类别.高通量筛选(hts)的改进显着加速了某些ppi抑制剂的发现.然而,适用于筛选多蛋白复合物的方法(例如由三种或更多种不同成分组成的复合物)的出现较慢.在这里,我们探索了一种使用重组多蛋白复合物(rmpc)的方法.作为模型系统,我们选择了热激蛋白70(hsp70),它是一种atp依赖性分子伴侣,可与包括dnaja2和bag2在内的伴侣伴侣相互作用.Hsp70及其协同分子之间的ppi刺激核苷酸循环.因此,为了重新创建此三元蛋白质系统,我们将纯化的人hsp70与dnaja2和bag2结合在一起,然后进行了100次筛选,000种化合物,可抑制伴侣伴侣刺激的atpase活性.这项hts运动产生了两种具有有希望的抑制活性的化合物.有趣的是,一种抑制hsp70和dnaja2之间的ppi,而另一种似乎抑制hsp70-Bag2复合体.使用二级分析,我们发现这
Doi:10.1074/jbc.Ra117.001575

专利信息

专利号:US-2008004415-A1
优先权日:2004-05-03
标题 :Non-linear optically active molecules, their synthesis, and use
发明人：MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B
权利人:OPTIMER PHOTONICS INC
摘要:In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a Ï€-donor conjugated to a Ï€-acceptor through a Ï€-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.

专利号:US-2012059163-A1
优先权日:2005-04-28
标题 :Non-linear opticaly active molecules, their synthesis, and use
发明人：MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B
权利人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B; OPTIMER PHOTONICS INC
摘要:In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a Ï€-donor conjugated to a Ï€-acceptor through a Ï€-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.