2,5-哌嗪二酮,3-甲基-1-(苯基甲基)-,(3S)-置于palladium On Activated Charcoal Lithium Aluminium Tetrahydride,氢气,溶剂黄146,三乙胺体系中,用 四氢呋喃,甲醇,二氯甲烷 用作溶剂,20.0 °C,101.33 Kpa 条件下,反应 80.0H,反应生成(S)-1-N-Boc-2-甲基哌嗪 参考文献:A Novel And Facile Method To Synthesize (R)‐ And (S)‐2‐methylpiperazine 标题:A Novel And Facile Method To Synthesize (R)‐ And (S)‐2‐methylpiperazine 摘要:A Concise And Efficient Synthesis Of (R)-And (S)-2-Methylpiperazine In Only Five Steps From (D)-And (L)-Alanine Is Described. The Key Step Is Reaction Of Benzylamine With A Bifunctional Molecule To Build A Six-Membered Ring. Doi:10.1081/scc-200036590
专利号:US-9676783-B2 优先权日:2008-10-22 标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds 发明人:HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN 权利人:ARRAY BIOPHARMA INC 摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
专利号:CN-1629146-A 优先权日:2003-12-19 标题 :Process for synthesis of chiral 2-substituted piperazine and its derivatives
专利号:DK-2725028-T3 优先权日:2008-10-22 标题:Substituted pyrazolo [1,5-a] pyrimidine compounds as intermediates in the synthesis of kinase inhibitors TRK
专利号:EP-2725028-A1 优先权日:2008-10-22 标题 :Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors
专利号:EP-2725028-B1 优先权日:2008-10-22 标题 :Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors
专利号:HU-E030413-T2 优先权日:2008-10-22 标 题:Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors