CAS: 147923-08-8; Boc-4-Phenyl-Phe-Oh

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128779-47-5 199110-64-0 205526-38-1

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methyl (S)-3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate N-B°C-4-I-Phe-OH phenylboronic acid 4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine-β-alanine benzyl ester(S)--β-alanine benzyl ester [(S)-2-Biphenyl-4-yl-1-(3-morpholin-4-yl-propylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester {(S)-2-Biphenyl-4-yl-1-[2-(4-hydroxy-phenyl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester [(S)-2-Biphenyl-4-yl-1-((S)-1-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

对溴肉桂酸置于双(乙腈)氯化钯(II),Ammonium Hydroxide,Caesium Carbonate体系中,用 四氢呋喃,水 用作溶剂,化学反应 24.66H,反应生成N-叔丁氧羰基-3-(4-联苯基)-L-丙氨酸
参考文献:Chemoenzymatic Synthesis Of Optically Purel-Andd-Biarylalanines Through Biocatalytic Asymmetric Amination And Palladium-Catalyzed Arylation
标题:Chemoenzymatic Synthesis Of Optically Purel-Andd-Biarylalanines Through Biocatalytic Asymmetric Amination And Palladium-Catalyzed Arylation
摘要:A Chemoenzymatic Approach Was Developed And Optimized For The Synthesis Of A Range Of N-Protected Nonnatural L-And D-Biarylalanine Derivatives. Starting From 4-Bromocinnamic Acid And 4-Bromophenylpyruvic Acid Using A Phenylalanine Ammonia Lyase (Pal) And An Evolved D-Amino Acid Dehydrogenase (Daadh),Respectively,Both Enantiomers Of 4-Bromophenylalanine Were Obtained And Subsequently Coupled With A Panel Of Arylboronic Acids To Give The Target Compounds In High Yield And Optical Purity Under Mild Aqueous Conditions.
Doi:10.1021/acscatal.5B01132