CAS: 147081-29-6; (S)-Tert-Butyl 3-Methylpiperazine-1-Carboxylate

相似化合物

1353006-46-8 163765-44-4 3023574-80-0

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号74879-18-8 (S)-(+)-2-甲基哌嗪 | CAS号136086-22-1 (S)-(-)1-(t-but... | CAS号150220-29-4 N-(tert-butoxyc... | CAS号58632-95-4 2-(叔-丁氧基碳酰胺)-2-苯乙腈 | CAS号15263-20-4 N-(叔丁氧羰氧基)邻苯二甲酰亚胺 | CAS号485841-52-9 (S)-1,2-二甲基哌嗪 | CAS号306298-24-8 (S)-叔丁基 4-((r)-...

(S)-(+)-2-甲基哌嗪 以94%的收率获得(S)-4-N-叔丁氧羰基-2-甲基哌嗪
参考文献:Piperazine And Homopiperazine Compounds
标题:Piperazine And Homopiperazine Compounds
摘要:提供了具有哌嗪或同源哌嗪环的化合物,这些化合物在治疗血栓症方面很有用.

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-12172982-B2
优先权日:2020-08-12
标 题:Synthesis of quinazoline compounds
发明人：LIM NGIAP-KIE; SHEN JEFF; SIROIS LAUREN ELIZABETH; TIMMERMAN JACOB C; TRACHSEL ETIENNE; WHITE NICHOLAS ANDREW; XU JIE; ZHANG HAIMING; BACHMANN STEPHAN; BIGLER RAPHAEL; CLAGG KYLE BRADLEY PASCUAL; DIPASQUALE ANTONIO GIOVANNI; GOSSELIN FRANCIS; ORCEL UGO JONATHAN; MEIER ROLAND CHRISTOPH
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.

专利号:US-12071422-B2
优先权日:2022-02-07
标 题 :Process for synthesis of quinazoline compounds
发明人：LEBL RENE; LIM NGIAP KIE; MEIER ROLAND CHRISTOPH; ORCEL UGO JONATHAN; SEDELMEIER JOERG; SHEN JEFF; SIROIS LAUREN ELIZABETH; TIMMERMAN JACOB C; TRACHSEL ETIENNE; WHITE NICHOLAS ANDREW; XU JIE; ZHANG HAIMING; BACHMANN STEPHAN; BASS THOMAS MICHAEL; BIGLER RAPHAEL; BURKHARD JOHANNES ADRIAN; CLAGG KYLE BRADLEY PASCUAL; GOSSELIN FRANCIS; HAN CHONG; KALDRE DAINIS; KELLY SEAN M; HEROLD SEBASTIAN; LEITNER CHRISTIAN
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

专利号:US-2023192682-A1
优先权日:2019-11-14
标题:Improved synthesis of kras g12c inhibitor compound

专利号:US-2023192681-A1
优先权日:2019-11-14
标 题 :Improved synthesis of kras g12c inhibitor compound