CAS: 126-49-8; 1-(2-Carboxy-2-Oxoethyl)-4-Hydroxycyclohexa-2,5-Diene-1-Carboxylic Acid

📜分支酸 反应生成(1-羧基-4-羟-2,5-环己二烯基)代丙酮酸
参考文献:Toromanoff,Edmond,C. R. Acad. Sci.,306,(1988) N 7,479-482
标题:Toromanoff,Edmond,C. R. Acad. Sci.,306,(1988) N 7,479-482

专利信息

专利号:WO-2025031833-A1
优先权日:2023-08-04
标 题:Recombinant strain and use thereof in production of scoulerine
发明人：CHEN YUN; JIAO XIANG
权利人:CHRYSEA LTD; CHEN YUN
摘要:Disclosed are recombinant yeast strains and a use thereof in the production of a benzylisoquinoline alkaloid. The recombinant yeast strains comprise berberine bridge enzyme. De novo synthesis of scoulerine and a benzylisoquinoline alkaloid is achieved through multiple strategies, and the yield thereof is significantly increased. The recombinant yeast strains provided by the present invention can produce scoulerine and other benzylisoquinoline alkaloids at high efficiency, and has important value in applications.

专利号:EP-1764415-A1
优先权日:2005-09-20
标 题 :Microbial production of p-hydroxybenzyl alcohol
发明人：VAN DER WERF MARIA JOHANNA
权利人:TNO
摘要:The invention relates to the production of aromatic compounds, in particular to the synthesis of aromatic compounds that are hydroxylated at the p (para)- or 4-position, such as p-hydroxybenzyl alcohol (p-HBA). Provided is a method for providing p-HBA, comprising the steps of providing a host cell which has an increased flux in the biosynthesis of at least one aromatic amino acid, allowing said host cell to produce p-HBA and isolating said p-HBA. The (recombinant) host cell is for example a bacterial cell which shows an increased production level of L-phenylalanine and/or L-tyrosine.

专利号:US-2010143990-A1
优先权日:2006-11-27
标 题 :Fermentative production of hydroxytyrosol
发明人：ACHKAR JUEHANE; FERRANDEZ ABEL
权利人:ACHKAR JUEHANE; FERRANDEZ ABEL
摘要:The present invention relates to a newly identified microorganisms capable of direct production of hydroxytyrosol (hereinafter also referred to as Hy-T) from a carbon source obtainable from the D-glucose metabolization pathway. The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of Hy-T. The invention also relates to genetically engineered microorganisms and their use for the direct production of Hy-T.

专利号:EP-1187930-B1
优先权日:1999-05-28
标题:A global regulator used to enhance the synthesis of aromatic substances
发明人：ROMEO TONY; TATARKO MATTHEW
权利人:UNIV NORTH TEXAS
摘要:The present invention provides genetically engineered microorganisms that increase carbon flow into the production of precursors and metabolic intermediates of the common aromatic pathway and pathways branching therefrom. Products obtained thereby are also encompassed by the invention.

专利号:US-2010317886-A1
优先权日:2009-06-11
标 题 :Synthesis of isotopically-labeled functionalized dienes
发明人：MARTINEZ RODOLFO A
权利人:MARTINEZ RODOLFO A
摘要:All labeled carbons are derived ultimately from CO, as carbon-13 is separated from its lighter isotope by cyrogenic distillation of carbon monoxide (CO). Creation of stereospecific and site-specific compounds used for starting materials will address growing demands for labeled compounds, including isotopically-labeled functionalized dienes. Functionalized diene compounds can be used as precursors for the production of isotopically labeled pharmaceuticals, biomolecules, and natural products.

专利号:US-12416029-B2
优先权日:2016-06-27
标 题 :Compositions and methods for making benzylisoquinoline alkaloids, morphinan alkaloids, thebaine, and derivatives thereof
发明人：FACCHINI PETER JAMES; CHEN XUE; COLBECK JEFFREY C; TUCKER JOSEPH E
权利人:ANTHEIA INC
摘要:Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids (“BIAsâ€?) such as alkaloid morphinan. The methods disclosed can be used to produce thebaine, oripavine, codeine, morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone, naltrexone, naloxone, hydroxycodeinone, neopinone, and/or buprenorphine. Compositions and organisms useful for the synthesis of BIAs, including thebaine synthesis polypeptides, purine permeases, and polynucleotides encoding the same, are provided.