专利号:US-9755163-B2 优先权日:2010-04-30 标 题:Synthesis of four coordinated palladium complexes and their applications in light emitting devices thereof 发明人:LI JIAN; TURNER ERIC 权利人:ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIV; ARIZONA BOARD OF REGENTS ACTING FOR OR ON BEHALF OF ARIZONA STATE UNIV 摘要:Synthesis of four coordinated palladium complexes and their applications in light emitting devices thereof.
专利号:US-9126995-B2 优先权日:2011-11-08 标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound 发明人:TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU 权利人:NISSAN CHEMICAL IND LTD 摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.
专利号:WO-03031376-A1 优先权日:2001-10-12 标 题 :Solid phase synthesis of substituted 1,5-benzodiazepine-2-one and 1,5-benzothiazepine-2-one 发明人:MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F 权利人:AVENTIS PHARMA INC; MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F 摘要:A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library generation and is thus important to rapid discovery or new therapeutic agents containing the base structure of 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one.
专利号:US-7138526-B1 优先权日:1999-06-15 标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives 发明人:HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M 权利人:AVENTIS PHARMA INC 摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries
专利号:US-6566292-B2 优先权日:2001-03-27 标 题 :Process for the enhancement of the cycle life of a zinc-chromium based catalyst in the synthesis of 2-methylpyrazine 发明人:POTHARAJU SEETHARAMANJANEYA SA; RAGHAVAN KONDAPURAM VIJAYA; RAO PANJA KANTA; KULKARNI SHIVANAND JANARDAN; RAO KATABATHINI NARASIMHA; GOPINATH RAJESH; FARSINAVIS SURESH; MESHRAM HARSHADAS MITARAM 权利人:COUNCIL SCIENT IND RES 摘要:The present invention relates to enhancement of the cycle life of a zinc chromium based catalyst used in the synthesis of 2-methylpyrazine by increasing the reaction temperature step-wise, starting from a low temperature, while monitoring the levels of total conversion and selectivity towards pyrazine. The catalyst can be regenerated after each cycle of use without substantial loss of activity.
专利号:US-6127515-A 优先权日:1997-11-18 标 题:Functionalized resin for the synthesis of amides and peptides 发明人:MANFRE FRANCO; VANASSE BENOIT J; LABAUDINIERE RICHARD F; MORTON GEORGE C 权利人:AVENTIS PHARM PROD INC 摘要:This invention is directed to a functionalized amino resin of formula ##STR1## wherein S is a solid support; R is H or alkyl; A is ##STR2## Y is OH or OCOR 1 ; and R 1 is aliphatic or aromatic which is useful for the solid phase synthesis of amides, peptides and hydroxamic acids.
[参考文献]: M Y Jung, Et Al. Effects Of Roasting On Pyrazine Contents And Oxidative Stability Of Red Pepper Seed Oil Prior To Its Extraction. J Agric Food Chem. 1999 Apr;47(4):1700-4. [参考文献]: Anita Toulmin, Et Al. Toward Prediction Of Alkane/water Partition Coefficients. J Med Chem. 2008 Jul 10;51(13):3720-30. [参考文献]: Florian E Kiene, Et Al. Orientation To Determine Quality Attributes Of Flavoring Excipients Containing Volatile Molecules. J Pharm Biomed Anal. 2015 Jun 10:110:20-6. [参考文献]: Gustavo Luis Leonardo Scalone, Et Al. Influence Of Free Amino Acids, Oligopeptides, And Polypeptides On The Formation Of Pyrazines In Maillard Model Systems. J Agric Food Chem. 2015 Jun 10;63(22):5364-72.
合成参考文献
参考文献:10.1107/s1600536811006234 摘要:Fischer J, Schmitt V, Schollmeyer D, Detert H. Monoclinic polymorph of 2,5-bis[4-(dimethyl-amino)-styr-yl]-3,6-dimethyl-pyrazine. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o875. 参考文献:10.1107/s1600536811015029 摘要:Ju Y, Wu JM, Li CP, Guo JH. 2,5-Bis(5-methyl-pyrazin-2-yl)-1,3,4-oxadiazole. Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 01;67(Pt 6):o1416.