CAS: 98475-07-1; Methyl 2-(Bromomethyl)-3-Nitrobenzoate

上下游产品

2-methyl-3-nitro-benzoic acid methyl ester dibenzoyl peroxide methyl 2-methyl-4-nitrobenzoate diethyl ether3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione 2-(3,5-dimethyl-phenyl)-4-nitro-2,3-dihydro-isoindol-1-one 4-nitroisoindolin-1-one 2-[4-(4-fluoro-benzyl)piperidin-1-ylmethyl]-3-nitro-benzoic acid methyl ester

2-甲基-3-硝基苯甲酸置于n-溴代丁二酰亚胺(Nbs),偶氮二异丁腈,硫酸体系中,用 苯 作为反应溶剂,化学反应 48.0H,反应生成 2-溴甲基-3-硝基苯甲酸甲酯
参考文献:通过顺序的pd催化胺化和aldol缩合反应有效合成dibenzazepine内酰胺
标题:通过顺序的pd催化胺化和aldol缩合反应有效合成dibenzazepine内酰胺
摘要:开发了一种简单而有效的反应来合成二苯并ze庚内酰胺衍生物.核心的7元氮杂环庚烷环是通过逐步步骤形成的,该步骤涉及钯催化的胺化反应和醛醇缩合反应.
DOI:10.1016/j.Tetlet.2019.151536

专利信息

专利号:US-10392364-B2
优先权日:2014-08-11
标题:Process for synthesis of lenalidomide
发明人：RAO RAMAKRISHNA; NANDIPATI RAMADEVI; GOODA RAVI; SHEWALKAR MUKESH PADMAKAR; BHADKE VENKAT VASANTRAO
权利人:AVRA LABORATORIES PVT LTD
摘要:Disclosed herein is an improved process for preparation of Lenalidomide and crystalline polymorphic forms thereof.

专利号:WO-2022144924-A1
优先权日:2021-01-04
标 题:An improved process for synthesis of lenalidomide
发明人：RAO RAMAKRISHNA; SHEWALKAR MUKESH PADMAKAR
权利人:AVRA LABORATORIES PVT LTD
摘要:The present invention discloses an improved process for preparation of Lenalidomide and crystalline polymorphic forms thereof. More particularly, the invention relates to preparation of Lenalidomide with high yields and purity and to preparation of crystalline polymorphic form A and Form B.

专利号:US-2018334443-A1
优先权日:2014-08-11
标题:An improved process for synthesis of lenalidomide

专利号:US-9522899-B2
优先权日:2009-06-01
标 题:Methods for synthesizing 3-(substituted dihydroisoindolinone-2-yl)-2, 6-dioxopiperidine, and intermediates thereof
发明人：YAN RONG; YANG HAO; XU YONGXIANG
权利人:NANJING CAVENDISH BIO-ENGINEERING TECH CO LTD; YAN RONG; NANJIAN CAVENDISH BIO-ENGINEERING TECH CO LTD
摘要:The present invention discloses methods for synthesizing 3-(substituted dihydroisoindolinone-2-yl)-2,6-dioxopiperidine and intermediates thereof, namely, the synthesis of compounds of the Formula (I), with each substitutional group defined in the patent specification. Owing to the advantages of high productivity, little influence to the environment and material accessibility, the methods of the present invention is suitable for industrial production.

专利号:WO-2016024286-A2
优先权日:2014-08-11
标 题 :An improved process for synthesis of lenalidomide

专利号:US-2003139451-A1
优先权日:2001-08-06
标题 :Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs