CAS: 951380-42-0; 5-[2-Cyclopropyl-1-(2-Fluorophenyl)-2-Oxoethyl]-4,5,6,7-Tetrahydrothieno[3,2-C]Pyridin-2(3H)-One

该化合物是一种结构复杂的异环化合物,其结构复杂,其核心为四氢异丙烯丙酮,具有环丙基和氟联苯的替代成分.该化合物独特的分子结构表明其在药用化学中具有潜在效用,特别是作为生物活性分子发展的中间分子或药用磷.氟联苯组的存在可能增强结合的亲和代相稳定性,而环丙基酮混合物则有助于符合的僵硬性.该化合物的精密合成途径和高纯度使其适合研究应用,包括药物发现和结构-活动关系研究.该化合物在标准实验室条件下的稳定性进一步支持其在探索化学中的使用.

结构式图片

物理性质

MSDS等安全信息

上下游产品

CAS号178688-43-2 2-氯-1-环丙基-2-(2-... | CAS号178688-49-8 4,5,6,7-四氢噻吩并[3... | CAS号1100905-46-1 3-cyclopropyl-1... | CAS号204205-33-4 2-溴-2-(2-氟苯基)-1... | CAS号178688-48-7 4,5,6,7-四氢噻吩并[3... | CAS号150322-73-9 1-环丙基-2-(2-氟苯基)乙酮 | CAS号150322-43-3 普拉格雷

合成工艺路线路线简述

  • 1263407-24-4 = 951380-42-0
    反应条件:1.1 Reagents: Acetic Acid Solvents: Ethanol; Ph 5,Rt1.2 Reagents: Hydrogen Peroxide Solvents: Water; 4 H,Rt1.3 Reagents: Sodium Thiosulfate Solvents: Water; Rt
    标题:An Improvement To The Preparation Of Prasugrel Hydrochloride
    作者:Ou,Wenhua; Yi,Weiyin; Liu,Feng; Pan,Xianhua; Peng,Xijiang
    参考文献:Journal Of Chemical Research 日期:2013 卷标:37(6) 页码:369-371]

    204205-33-4 + 115473-15-9 = 951380-42-0
    反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Dimethylformamide,Toluene; 25 °C -> 45 °C
    标题:A Process For The Preparation Of Prasugrel
    参考文献:India]

    178688-48-7 + 1100905-46-1 = 951380-42-0
    反应条件:1.1 Reagents: Tetrabutylammonium Bromide Solvents: Dichloromethane; 20 H,Rt -> Reflux
    标题:Process For The Manufacturing Of 5-[2-Cyclopropyl-1-(2-Fluorophenyl)-2-Oxoethyl]-4,5,6,7-Tetrahydrothieno[3,2-C]Pyridin-2-Yl Acetate (Prasugrel)
    参考文献:World Intellectual Property Organization]

    = 951380-42-0 [标题:Reaction Conditions
    标题:A Method For The Manufacture Of Highly Pure Prasugrel
    参考文献:World Intellectual Property Organization]

    = 951380-42-0 [标题:Reaction Conditions
    标题:Oral Dosage Forms Including An Antiplatelet Agent And An Acid Inhibitor
    参考文献:World Intellectual Property Organization]

    104-15-4 + 178688-48-7 + 204205-33-4 = 951380-42-0 + 150322-43-3
    反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Acetonitrile; < 30 °C; 30 Min,< 30 °C1.2 Reagents: Diisopropylethylamine Catalysts: 4-(Dimethylamino)Pyridine; 1.5 - 2 H,Rt; Rt -> -15 °C1.3 Solvents: Water; 1.5 - 2 H,-15 - -6 °C
    标题:Method Of Producing Highly Pure Prasugrel And Pharmaceutically Acceptable Salts Thereof
    参考文献:World Intellectual Property Organization]

    115473-15-9 + 1100905-46-1 = 951380-42-0
    反应条件:1.1 Reagents: Potassium Bicarbonate Solvents: Acetonitrile; Rt -> 40 °C1.2 3 H,40 °C
    标题:Process For Preparation Of 2-Cyclopropyl-1-(2-Fluorophenyl)-2-Oxoethanol Derivatives As Intermediate Compounds For Preparing Prasugrel
    参考文献:China]

    1236042-90-2 = 951380-42-0
    反应条件:1.1 Reagents: Pyridinium Chlorochromate Solvents: Dichloromethane; 3 H,Rt
    标题:New Method For Preparing Prasugrel
    参考文献:China]

    178688-48-7 + 150322-73-9 = 951380-42-0
    反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Carbon Tetrachloride; 8 H,76 - 78 °C; 78 °C -> 30 °C1.2 Reagents: Potassium Carbonate Solvents: Acetonitrile; 5 H,25 - 30 °C
    标题:Improved Process For Preparing Prasugrel
    参考文献:India]

    204205-33-4 + 115473-15-9 = 951380-42-0
    反应条件:1.1 Reagents: Sodium Carbonate Solvents: Methyl Isobutyl Ketone; 10 H,40 °C
    标题:Process For The Preparation Of High-Purity Prasugrel
    参考文献:Hungary]

    204205-33-4 + 115473-15-9 = 951380-42-0
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetonitrile; 20 - 25 °C; 25 °C -> 5 °C1.2 Solvents: Acetonitrile; 30 - 45 Min,0 - 5 °C; 5 H,0 - 5 °C
    标题:An Improved Process For The Preparation Of Prasugrel Hydrochloride
    参考文献:India]

    178688-48-7 + 204205-33-4 = 951380-42-0
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 5 H,25 - 30 °C
    标题:A Process For The Preparation Of Cyclopropyl(Fluorophenyl)Ethanone
    参考文献:India]

    178688-48-7 + 204205-33-4 = 951380-42-0
    反应条件:1.1 Reagents: Potassium Bicarbonate Solvents: Acetonitrile; Rt -> 15 °C; 10 - 15 °C; 2 H,10 - 15 °C; 2 - 3 H,10 - 15 °C
    标题:Process For The Preparation Of 2-Acetoxy-5-(α-Cyclopropylcarbonyl-2-Fluorobenzyl)-4,5,6,7-Tetrahydrothieno[3,2-C]Pyridine
    参考文献:World Intellectual Property Organization
📜2-氟溴苄置于碘甲烷 1,3-二溴-5,5-二甲基海因,偶氮二异丁腈,Potassium Hydrogencarbonate,Magnesium体系中,用 乙醚,环己烷,乙腈 作为反应溶剂,化学反应生成 5-[2-环丙基-1-(2-氟苯基)-2-氧代乙基]-4,5,6,7-四氢噻吩并[3,2-C]吡啶-2(3H)-酮
参考文献: Process For The Preparation Of 2-Acetoxy-5-(A-Cycloprpylcarbonyl-2-Fluorobenzyl)-4,5,6,7-Tetrahydrothieno[3,2-C]Pyridine[fr] Procédé De Préparation De 2-Acétoxy-5-(-Cyclopropylcarbonyl-2-Fluorobenzyl)-4,5,6,7-Tétrahydrothiéno[3,2-C]Pyridine
标题: Process For The Preparation Of 2-Acetoxy-5-(A-Cycloprpylcarbonyl-2-Fluorobenzyl)-4,5,6,7-Tetrahydrothieno[3,2-C]Pyridine[fr] Procédé De Préparation De 2-Acétoxy-5-(-Cyclopropylcarbonyl-2-Fluorobenzyl)-4,5,6,7-Tétrahydrothiéno[3,2-C]Pyridine
摘要:本发明涉及一种制备2-乙酰氧基-5-(α-环丙基羰基-2-氟苯甲基)-4,5,6,7-四氢噻吩[3,2-C]吡啶及其药用可接受盐的方法,使用2-乙酰氧基-四氢噻吩吡啶衍生物,即式(vi)和(viii)化合物或其盐或5-(α-环丙基羰基-2-氟苯甲基)-2-氧代-4,5,6,7-四氢噻吩[3,2-C]吡啶的酸加盐,即式(II).本发明还涉及制备2-乙酰氧基-四氢噻吩吡啶衍生物,即式(vi)和(viii)化合物或其盐以及化合物的酸加盐的方法.

海关参考信息

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2010).
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知