CAS: 94651-33-9; 2-(Trifluoromethoxy)Benzaldehyde

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CAS号456-55-3 三氟甲氧基苯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号1262424-69-0 2-[o-(trifluoro... | CAS号7035-09-8 5-氯-2-甲氧基苯甲醛 | CAS号914636-53-6 3-[2-(Trifluoro...

2-[o-(Trifluoromethoxy)Phenyl]Glyoxylic Acid 600.0 °C,0.0 Pa 条件下,反应生成 2-(三氟甲氧基)苯甲醛
参考文献:分子内羟基卡宾ch-插入:(邻甲氧基苯基)羟基卡宾的奇怪案例.
标题:分子内羟基卡宾ch-插入:(邻甲氧基苯基)羟基卡宾的奇怪案例.
摘要:通过高真空闪蒸热解 (Hvfp) 和随后的基质分离,实验观测到气相中羟基卡宾的首次 Ch 插入:(邻甲氧基苯基)乙醛酸在热解时产生不可分离的(邻甲氧基苯基)羟基卡宾在 600 摄氏度时,它迅速插入甲基 Ch 键.插入产物 2,3-二氢苯并呋喃-3-醇在 11 K 下被捕获在过量的 Ar 中,并通过红外光谱进行表征.插入过程在动力学上超过了邻茴香醛的替代[1,2]H隧道反应,这是在其他羟基卡宾中观测到的一种反应.还检测到痕量的脱水产物苯并[b]呋喃.包括插入和氢迁移过程的势能超表面是在全电子耦合团簇理论水平上计算的,包括单取代和双取代,并微扰地包括三重激发[ae-Ccsd(T)]以及相关一致的双取代-Zeta 基组 (Cc-Pvdz),利用密度泛函理论 (Dft) 优化几何结构 (M06-2X/cc-Pvdz) 和零点振动能量 (Zpve) 校正.将甲氧基交换为三氟甲氧基成功地阻止了插入,并
DOI:10.3762/bjoc.6.121

专利信息

专利号:US-8129560-B2
优先权日:2005-08-15
标 题 :Process for the synthesis of mandipropamid and derivatives thereof
发明人：BOWDEN MARTIN CHARLES; CLARK THOMAS AITCHESON; GIORDANO FANNY; JAU BEAT; SCHNEIDER HANS-DIETER; SEIFERT GOTTFRIED; ZELLER MARTIN; FABER DOMINIK; WISS JUERG
权利人:BOWDEN MARTIN CHARLES; CLARK THOMAS AITCHESON; GIORDANO FANNY; JAU BEAT; SCHNEIDER HANS-DIETER; SEIFERT GOTTFRIED; ZELLER MARTIN; FABER DOMINIK; WISS JUERG; SYNGENTA CROP PROT INC
摘要:A process for the preparation of a compound of formula (I), the process comprising: (i) the reaction of a compound of formula (III), with a compound of formula (IV) to give a compound of formula (II), and (ii) the reaction of the compound of formula (II) with a leaving group, to give the compound of formula (I).

专利号:US-4438043-A
优先权日:1982-04-22
标题:Process for preparation of di- or trifluoromethoxyphenyl ketones or di- or trifluoromethylthiophenyl ketones
发明人：DESBOIS MICHEL
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the preparation of di- or trifluoromethoxyphenyl ketones or di- or trifluoromethylthiophenyl ketones, characterized in that, in a first stage, a di- or trihalomethoxybenzene or a di- or trihalomethylthiobenzene is reacted with a trihalomethylated aromatic or aliphatic compound in the presence of boron trifluoride in an amount such that the absolute pressure of boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent and in that, in a second stage, the product of the first stage is hydrolyzed. The resultant products are useful as intermediates in the synthesis of compounds having a pharmaceutical or phytosanitary (e.g., herbicidal) activity.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-5721255-A
优先权日:1992-08-19
标 题 :Substituted benzylamino nitrogen containing non-aromatic heterocycles
发明人：HOWARD HARRY R; NAKANE MASAMI; IKUNAKA MASAYA; SATAKE KUNIO; ROSEN TERRY J; LOWE III JOHN A; O'NEILL BRIAN T; ITO FUMITAKA
权利人:PFIZER
摘要:The present invention relates to novel substituted benzylamino nitrogen containing non-aromatic heterocycles and, specifically, to compounds of the formula ##STR1## wherein W, R 1 , R 2 , R 3 and A are as defined in the specification, and to intermediates used in the synthesis of such compounds. The novel compounds of formula I are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.

专利号:CA-2619435-A1
优先权日:2005-08-15
标 题:Process for the synthesis of mandipropamid and derivatives thereof