CAS: 912-60-7; 6,7-Dimethoxy-3-((R)-4-Methoxy-6-Methyl-5,6,7,8-Tetrahydro-[1,3]Dioxolo[4,5-G]Isoquinolin-5-yl)Isobenzofuran-1(3H)-One Hydrochloride
- 英文名称6,7-Dimethoxy-3-((R)-4-Methoxy-6-Methyl-5,6,7,8-Tetrahydro-[1,3]Dioxolo[4,5-G]Isoquinolin-5-yl)Isobenzofuran-1(3H)-One Hydrochloride
- 中文名称诺司卡品 盐酸盐 水合物
- IUPAC名称6,7-dimethoxy-3-((R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one hydrochloride
- 其它别名NOSCAPINE HYDR°CHLORIDE; NARCOTINE HYDR°CHLORIDE; (3S)-6,7-DIMETHOXY-3-[(5R)-5,6,7,8-TETRAHYDRO-4-METHOXY-6-METHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLIN-5-YL]-1(3H)-ISOBENZOFURANONE HYDR°CHLORIDE; ,3-dioxolo(4,5-g)isoquinolin-5-yl)-,hydr°Chloride,(s-(r*,s*))-; 1(3h)isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1; 1-alpha-narcotinehydr°Chloride; capvalhydr°Chloride; coscopinhydr°Chloride
- CAS编号912-60-7
- MFCD编号:MFCD00082546
- EINECS号:213-014-9
- 分子式:C22H24ClNO7分子量:449.89
- 产品CID: 1947638
- 同类组份化合物CAS128-62-1 (free base)25333-79-3 (camphorsulfonate)912-60-7 (HCl)106611-48-7 (embonate)
- 产品分类原料药 → 呼吸系统用药 → 镇咳药
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: MFLVZFXCSKVCSH-URBRKQAFSA-N
- MFLVZFXCSKVCSH-FSKSRBAZNA-N
- 计算化学: 氢键受体数8.0氢键供体数1.0可旋转键数4.0
物理性质
- 熔点221-223 °C
- 沸点565.3 °C at 760mmHg
- 闪点295.7 °C
- 密度1.332g/cm3
- PSA:75.69
- LogP:3.6217
- 折射率1.6
- 蒸汽压8.42E-13 mmHg at 25 °C
- 溶解性Freely Soluble In Water And In Ethanol (96 Per Cent). Aqueous Solutions Are Slightly Acid; The Base May Be Precipitated When The Solutions Are Allowed To Stand.
- 敏感性白色结晶性粉末。有吸湿性。易溶于水形成碱式盐。熔点221～223°C。比旋光度[α]D20 +71°（C=0.5，乙醇中）。有致遗传损害的可能性 白色结晶性粉末。有吸湿性。易溶于水形成碱式盐。熔点221～223°C。比旋光度[α]D20 +71°（C=0.5，乙醇中）。有致遗传损害的可能性
- 外观形态晶体固体
- 储存条件2-8°C
- 产品应用该化合物是一种源自罂粟(PAPAVER SOMNIFERUM)的类阿片类碱,是一种用于治疗持久性非生产性咳嗽的非致瘾性抗咳剂(咳嗽药),NOSCAPINE的抗效应似乎主要通过它的"受体"刺激活动来调解,这种机制的证据是由老鼠实验证据提供的;对白喉(一种有特性的对立体)的预处理,导致无斯CAPIN抗USSIVE活动的剂量下降.据知,NOSTAPINE及其合成衍生物"无脊椎"与微细胞相互作用,抑制癌症细胞扩散.NSCAPIN HCL 停止了.
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别急性毒性 类别4(经口)
Muta. 1B
急性毒性 类别3(吸入)
急性毒性 类别3(经皮)
急性毒性 类别3(经口)
致突变性 类别2
呼吸道致敏 类别1
皮肤致敏 类别1 - 警示词Warning(警告)
- 危险描述H302 |吞咽有害.
H340 |可能导致遗传缺陷.
H331 |吸入会中毒.
H311 |皮肤接触会中毒.
H301 |吞咽会中毒.
H341 |怀疑导致遗传缺陷.
H334 |吸入可能引起过敏或哮喘症状或呼吸困难.
H317 |可能引起皮肤过敏反应. - 防范说明P301+P312+P330
- 危险等级6.1(b)
- UN编号1544
- 危险品标志Xn,Xi
- 包装等级III
- 安全声明36
- 危险类别码22
- WGK Germany3
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号4593-97-9 6-methoxy-1-met... | CAS号569-31-3 6,7-二甲氧基-3H-1-异苯并呋喃酮 | CAS号550-10-7 hydr°Cotarnine | CAS号19641-12-4 6-methoxy-1,2-d...合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2906210000-苄醇
2907210001-间苯二酚
2907221000-对苯二酚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6800663-B2
优先权日:2002-10-18
标 题:Crosslinked hydrogel copolymers
发明人：ASGARZADEH FIROUZ; COSTANTINO HENRY R
权利人:ALKERMES INC
摘要:The present invention relates to crosslinked polymers, synthesized through ring-opening polymerization of ethylenically unsaturated epoxides, in combination with α-hydroxy acids using a hydrophilic macroinitiator, such as poly(ethylene glycol), to form substituted copolymers having ethylenically unsaturated functionality randomly distributed along the polyester polymer backbone. That copolymer is subsequently crosslinked to form a hydrogel network. More particularly, the present invention relates to the synthesis of biodegradable poly(α-hydroxy acid-co-glycidyl methacrylate)-block-poly(ethylene glycol)-block-poly(α-hydroxy acid-co-glycidyl methacrylate) copolymers, which are subsequently crosslinked to form hydrogel networks. The invention also relates to the use of these hydrogel networks in various applications, in particular, for the controlled release of drugs and proteins.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Gali-Muhtasib H, Hmadi R, Kareh M, Tohme R, Darwiche N. Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis. Apoptosis. 2015 Dec;20(12):1531-62. doi: 10.1007/s10495-015-1169-2. Review. doi: 10.1002/med.21357. Review.
3: Chen X, Dang TT, Facchini PJ. Noscapine comes of age. Phytochemistry. 2015 Mar;111:7-13. doi: 10.1016/j.phytochem.2014.09.008. Review. doi: 10.1016/j.pharep.2014.09.003. Review. doi: 10.2105/AJPH.2014.301966. Review.
6: Fang ZZ, Gonzalez FJ. LC-MS-based metabolomics: an update. Arch Toxicol. 2014 Aug;88(8):1491-502. doi: 10.1007/s00204-014-1234-6. Review. doi: 10.1007/s00425-014-2056-8. Review. Review. doi: 10.1097/CAD.0b013e32835ec414. Review. doi: 10.1093/pcp/pct020. Review. Review. Review. Dutch. doi: 10.1007/s11095-012-0809-2. Review. Review. Review. doi: 10.4045/tidsskr.08.0438. Review. Norwegian. Review. doi: 10.1021/np800568j. Review. Erratum in: J Nat Prod. 2011 May 27;74(5):1352.
合成参考文献
摘要:Journal of Pharmacology and Experimental Therapeutics., 123(287), 1958 []
📝 需求与反馈
尽可能描述清楚需求与问题信息
