CAS: 884494-44-4; (2-Chloro-4-Iodopyridin-3-yl)Methanol

主要参考文献

参考标题: Ligand-Controlled C(Sp3)-H Arylation And Olefination In Synthesis Of Unnatural Chiral Alpha Amino Acids Arylation Commandée Par Ligand De C(Sp3)-H Et Oléfination Utilisables Dans Le Cadre De La Synthèse D'Acides Alpha-Aminés Chiraux Non Naturels
摘要:The Use Of Ligands To Tune The Reactivity And Selectivity Of Transition Metal-Catalysts For C(-Sp3)-H Bond Functionalization Is A Central Challenge In Synthetic Organic Chemistry. Herein, We Report A Rare Example Of Catalyst-Controlled C(Sp3)-H Arylation Using Pyridine And Quinoline Derivatives: The Former Promotes Exclusive Monoarylation, Whereas The Latter Activates The Catalyst Further To Achieve Diarylation. Successive Application Of These Ligands Enables The Sequential Diarylation Of A Methyl Group In An Alanine Derivative With Two Different Aryl Iodides, Affording A Wide Range Of β-Ar-P-Ar ' -Cc-Amino Acids With Excellent Levels Of Diastereoselectivity (D.R. > 20:1). Both Configurations Of The β-Chiral Center Can Be Accessed By Choosing The Order In Which The Aryl Groups Are Installed. The Use Of A Quinoline Derivative As A Ligand Also Enables C(Sp3)-H Olefination Of A Protected Alanine.