CAS: 84468-15-5; Isoquinoline-5-Sulfonyl Chloride

该化合物是有机合成和制药研究中广泛使用的一种多种用途的灭菌试剂,其主要优点包括作为磺酰胺剂的高反应性,能够有效地将磺酰氟功能组引入目标分子中. 等离子脊柱提供了结构稳定性,提高了反应的选择性. 这种化合物在合成磺酰胺方面特别有用,因为磺酰胺是药物开发的重要中间体. 它定义明确的再活性特征和与各种基质的兼容性,使它成为研究人员的可靠选择. 建议在水性条件下进行适当处理,因为其湿度敏感. 该产品通常作为高纯度固体供应,以便在合成应用中达到最佳性能.

结构式图片

相似化合物

105627-79-0 748752-50-3 1374652-25-1

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上下游产品

CAS号27655-40-9 异喹啉-5-磺酸 | CAS号105627-79-0 异喹啉-5-磺酰氯盐酸盐 | CAS号110883-96-0 1-isoquinolin-5... | CAS号141543-63-7 1-(5-异喹啉磺酰基)哌嗪盐酸盐 | CAS号92564-34-6 HA 1004 盐酸盐 | CAS号84468-17-7 N-(2-氨基乙基)异喹啉-5-磺酰胺 | CAS号105628-07-7 盐酸法舒地尔 | CAS号103745-39-7 法舒地尔 | CAS号116700-36-8 N-(2-氨乙基)-5-异喹啉... | CAS号113276-94-1 H-8 二氢氯化物 | CAS号141543-65-9 1-(5-异喹啉磺酰基)-3-...

合成工艺路线路线简述

    📜异喹啉置于氯化亚砜,硫酸体系中,化学反应生成 异喹啉-5-磺酰氯
    参考文献:Isoquinolinesulfonyl Derivative As Rho Kinase Inhibitor
    标题:Isoquinolinesulfonyl Derivative As Rho Kinase Inhibitor
    摘要:本发明公开了一类异喹啉磺酰衍生物作为rho激酶抑制剂,以及其药物组合物,并涉及它们的药用可接受用途.具体而言,本发明涉及如式(I)所示的化合物,或其药用可接受的盐.

    海关参考信息

    专利信息


    专利号:UA-68408-C2
    优先权日:1998-12-23
    标 题:3-azabicyclo[3.1.0]hexane derivatives as opiate receptor ligands, pharmaceutical and veterinary composition, method for treatment and method for synthesis of derivatives

    专利号:US-12264146-B2
    优先权日:2018-10-30
    标 题 :Rho kinase inhibitor, method for preparing same and uses thereof
    发明人：ZHANG BAOXIAN; ZHANG HONGWU; HU JIE; KANG ZHIYUN; XUE CHUNMEI; LI WENHUI; SONG YANWEI; WU ZHENZHEN; CHEN ANPING; WANG FANG; REN HENGCHUN; LI JUN
    权利人:BEIJING INCREASE INNOVATIVE DRUG CO LTD
    摘要:Provided are a Rho kinase inhibitor, a method for preparing same and the uses thereof. The Rho kinase inhibitor designates a compound of Formula I, a stereoisomer thereof or pharmaceutically acceptable salt thereof. The Rho kinase inhibitor promotes endothelial cells and endothelin expression, prostenin expression, and vascular factors NO synthesis and secretion, has a promoting effect on proprostin expression independently of the doses used, shows lower toxicity, while being safer.

    专利号:CN-102603715-A
    优先权日:2012-03-31
    标 题 :A kind of synthesis and preparation method of fasudil hydrochloride

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    主要参考文献

    参考标题:Synthesis Of Sulfonyl Azides Via Diazotransfer Using An Imidazole-1-Sulfonyl Azide Salt: Scope And 15N Nmr Labeling Experiments
    作者:Marc Y. Stevens,Rajiv T. Sawant,Luke R. Odell |发布日期:2014.6.6
    摘要:Imidazole-1-Sulfonyl Azide Hydrogen Sulfate Is Presented As An Efficient Reagent For The Synthesis Of Sulfonyl Azides From Primary Sulfonamides. The Described Method Is Experimentally Simple And High-Yielding And Does Not Require The Addition Of Cu Salts. Furthermore, 15N Nmr Mechanistic Studies Show The Reaction Proceeds Via A Diazo Transfer Mechanism. Imidazole-1-Sulfonyl Azide Hydrogen Sulfate Provides

    合成参考文献


    摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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