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专利信息
专利号:US-6248866-B1
优先权日:1997-10-31
标 题:Hypusine reagent for peptide synthesis
发明人:BERGERON JR RAYMOND J
权利人:UNIV FLORIDA
摘要:A derivative of hypusine useful as a reagent for synthesizing peptides containing hypusine, as well as an improved method for synthesizing the same, the derivative having the formula:wherein: Q1 and Q2 may be the same or different and are amino protective groups; Q3 is an amino protective group which is orthogonal to Q1 and Q2; and Z is a hydroxy protective group.
专利号:US-6258931-B1
优先权日:1998-08-19
标 题 :Deoxyhypusine reagent and peptides
发明人:BERGERON JR RAYMOND J
权利人:UNIV FLORIDA
摘要:The invention relates to a method and reagent for the synthesis of peptides containing deoxyhypusine, the reagent having the formula: n wherein: n Q 1 and Q 2 may be the same or different and are amino protective groups, n and Q 3 is an amino protective group which is orthogonal to Q 1 and Q 2 . n The invention also relates to peptides of formula n n n S-deoxyHpu-T  (2) n n n that may be synthesized using the reagent of the invention, wherein deoxyHpu is the deoxyhypusine residue, S and T are each independently peptide residues from zero to 12 amino acids in length.
专利号:US-6492491-B1
优先权日:1997-10-31
标题:Method of making hypusine peptides
发明人:BERGERON JR RAYMOND J
权利人:UNIV FLORIDA
摘要:The invention relates to novel peptides synthesized according a method utilizing the hypusine reagent: n wherein: Q 1 Q 2 and Q 3 may be the same or different and are amino protective groups, provided that Q 3 is orthogonal to Q 1 and Q 2 ; and n Z is a hydroxy protective group, n as well as improved methods of peptide synthesis wherein the above-described hypusine reagent is employed to prepare novel hypusine-containing peptides.