CAS: 75251-24-0; 1-(4-Ethylphenyl)Propan-2-One

上下游产品

2-acetyl-(4-ethylphenyl)acetonitrile mercury (II) chloride aluminium 4-methoxyphenyl 1H-imidazole-1-sulfonate 4-(4-ethylphenyl)-3-methyl-3-butenoic acid 4-(4-ethylphenyl)-3-methyl-2-butenoic acid 4-Ethyl-α-methyl-α-(phenylamino)benzolpropannitril (E)-1-(4-Ethyl-phenyl)-3-(3-nitro-phenyl)-propenone

📜2-Acetyl-(4-Ethylphenyl)Acetonitrile置于硫酸,水体系中,化学反应生成 4-乙基苯基丙酮
参考文献:Quantitative Relations Between Structure And Activation Of Fibrinolysis In Selected Series Of Arylaliphatic Acids
标题:Quantitative Relations Between Structure And Activation Of Fibrinolysis In Selected Series Of Arylaliphatic Acids
摘要:这篇论文描述了芳基醋酮ix与三乙基磷酸乙酯反应,反应生成4-芳基-3-甲基-2-丁烯酸酯x和4-芳基-3-甲基-3-丁烯酸酯x'.它们的水解产生了异构酸i和i'的混合物,其组成通过1H NMR谱进行了研究.还制备了3-甲基-3-苯基-2-丙烯酸ii,2-芳基-2-羟基丙酸iv和取代的α-苄氧基苯乙酸v.这些酸,连同芳基氧代脂肪酸iii,被研究其在激活纤溶作用中的功效.所研究的酸的亲脂性通过分配系数(酸ia和iia)或通过分配色谱法在正辛醇-水(ph 3.5)体系中确定.实验值log P与从片段常数f和参数π计算得到的值进行了比较.对于酸v,亲脂性的降低类似于观测到的芳基氧代脂肪酸.对于酸i,I'和ii,纤溶能力与亲脂性成正比.尽管我们评估了酸i和i'的混合物的纤溶能力,但线性关系与先前得出的一组芳基脂肪酸的结果一致.酸iii和iv中连接链上的功能基团对纤溶能力有负面影响.纤溶能力的降低可能是由于功能基团能够形成氢键.
DOI:10.1135/cccc19840122

专利信息

专利号:US-2004138495-A1
优先权日:1997-10-09
标题:Combinatorial preparation of phosphorus-containing active compounds and intermediates by solid phase synthesis
发明人：HAAF KLAUS; PATEK MARCEL
权利人:HAAF KLAUS; PATEK MARCEL
摘要:The invention relates to solid phase processes for the systematic preparation of chemical compounds from the group of the phosphonous or phosphinic acids and/or derivatives thereof and the corresponding substance libraries which can be employed for test purposes, in particular tests for biological activity. The compounds n YR 1 P(â•?O)(OR 3 )R 2   (I) n in which Y, R 1 , R 2 , R 3 are as defined in claim 1 are prepared by reacting a resin-linker adduct (II) n [resin polymer]-[linker-Z-E 1 -S 1 ] n n in the presence of a suitable Pd catalyst with a phosphinate (III) n A 1 -O—(PHO)A â–¡   (III) n with substitution of the group S 1 to give the compound (IV) n [resin polymer]-[linker-Z-E 1 -P(H)(â•?O)—OA 1   (IV) n and cleaving the compound (I) after derivatization reactions on the resin from the resin-linker adduct. n The invention also provides the intermediate steps and resin-linked intermediate compounds and also the substance libraries obtained.

专利号:EP-1200824-B1
优先权日:1999-06-15
标题:Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives