CAS: 70381-75-8; Anagrelide Impurity 6 Hbr

该化合物是一种化学化合物,其特点是结构复杂,包括一个配有二氯替代品的五氯基芯和一个非碘组;该化合物一般是晶状固体,在极地溶剂中可溶解,反映其功能组;乙乙酸乙酸盐的存在表明它可能表现出温和的亲脂性,从而影响其生物活动和药用植物.氢溴化盐形式在水溶性中强化其溶性,使之适合医药化学的各种应用.这种性质的化合物往往因其潜在的药用特性,包括抗扰动剂或抗微生物活动而受到调查,因为五氯酸盐酸盐的出现,因为其生物影响多种多样.安全和处理预防措施至关重要,因为许多卤化化合物具有潜在的毒性和环境关切,因此对它具有溶解性.

英文名称Anagrelide Impurity 6 Hbr
中文名称阿那格雷 6
IUPAC名称Anagrelide Related Compound C
其它别名Ethyl-5,6-Dichloro-3,4-Dihydro-2(1H)Imino Quinazoline-3-Acetate Hydrobromide; Ethyl 5,6-Dichloro-Dihydro-2(1H)-Iminoquinazoline-3-Acetate; Anagrelide Related Compound C (25 Mg) (Ethyl 2-(5,6-Dichloro-2-Imino-1,2-Dihydroquinazolin-3(4H)-yl)Acetate); 2-Amino-5,6-Dichloro-3(4H)-Quinazoline Acetic Acid Ethyl Ester Hydrobromide; Anagrelide Ethyl Ester; Anagrelide Impurity 6 Hbr; Anagrelide Related Compound C; Ethyl-5,6-Dichloro-3,4-Dihydro-2(1H)Imino Qu...
CAS编号70381-75-8
MFCD编号:MFCD12756005
EINECS号:893-420-6
FDA UNII编号:12WV68THBT
分子式:C12H14BrCl2N3O2分子量:383.07
产品CID: 1697786
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: UIACKXKZPDPMBY-UHFFFAOYSA-N
InChI=1S/C12H13Cl2N3O2.BrH/c1-2-19-10(18)6-17-5-7-9(16-12(17)15)4-3-8(13)11(7)14;/h3-4H,2,5-6H2,1H3,(H2,15,16);1H
计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数4.0

MSDS等安全信息

警示词Warning
危险描述H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H336 (100%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]
H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H362 (100%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]
防范说明P203, P260, P261, P263, P264, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P318, P319, P321, P330, P333+P317, P362+P364, P403+P233, P405, and P501
UN编号NONH for all modes of transport
WGK Germany3

上下游产品

brom°Cyane N-(6-amino-2,3-dichlorobenzyl)glycine ethyl esteranagrelide

合成工艺路线路线简述

合成目标产物 Ethyl 5,6-Dichloro-3,4-Dihydro-2(1H)-Iminoquinazoline-3-Acetate Hydrobromide 主要起始原料 Cyanogen Bromide And Ethyl N-(2,3-Dichloro-6-Aminobenzyl)Glcycine
(文献来源)合成步骤主要原料 Cyanogen Bromide 和 Ethyl N-(2,3-Dichloro-6-Aminobenzyl)Glcycine

📜2,3-二氯苯甲醛置于盐酸,甲醇,Sodium Tetrahydroborate,氯化亚砜,硫酸,硝酸,溶剂黄146,三乙胺,Tin(Ll) Chloride体系中,用 1,4-二氧六环,乙醇,水,甲苯作为反应溶剂,化学反应 6.0H,反应生成 5,6-二氯-3,4-二氢-2(1H)-亚胺喹唑啉-3-乙酸乙酯氢溴酸盐
参考文献:Wo2024180371A1
标题:Wo2024180371A1