CAS: 6020-87-7; 2-(1-Methylguanidino)Acetic Acid Hydrate

上下游产品

CYANAMID sodium sarcosinate sarcosine 2-{[amino(imino)methyl]sulfanyl}acetic acidcreatinine Creatinine

氰胺,Sodium Sarcosinate置于甲酸,水体系中,用 水 作为反应溶剂,20.0~52.0 °C,266.64 Kpa 条件下,反应 6.0H,以20 Mbar Pressure,There Were Obtained 165.2 G (67.1% Of Theory) Creatine Monohydrate的收率获得产物一水肌酸
参考文献:Process For The Preparation Of A Creatine Or Creatine Monohydrate
标题:Process For The Preparation Of A Creatine Or Creatine Monohydrate
摘要:本发明公开了一种制备肌酸或肌酸单水合物的方法,其中氰胺在水或水和有机溶剂混合物中与钠或钾肌氨酸反应,反应温度在20至150°C,Ph值在7.0至14.0之间.通过本发明的方法,可以以60至90%的重量收率和非常高的纯度制备肌酸或肌酸单水合物.

专利信息

专利号:WO-2004031133-A1
优先权日:2002-10-04
标 题:Process for the synthesis of guanidine derivatives
发明人：EISENHUTH LUDWIG
权利人:FLEXSYS BV; EISENHUTH LUDWIG
摘要:The invention pertains to a process for the synthesis of guanidine derivatives of Formula (I) wherein X is selected from OH, OM wherein M is an alkali or earth alkali metal ion, and NR1R2 wherein R1 and R2 are independently H, C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl, or C6-C10 aryl; which comprises a first step of reacting cyanogen chloride (N≡CCI) with NH3 in an organic solvent followed by a second step of reacting with an amine of Formula (II) wherein X has the previously given meaning, optionally followed by a step of converting a compound of Formula (I) into another compound of Formula (I).

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2022370393-A1
优先权日:2019-10-16
标 题 :Method and composition for increasing muscle protein synthesis
发明人：BELLAMINE AOUATEF; GLAB STANISLAW; DURKEE SHANE
权利人:CAPSUGEL BELGIUM NV
摘要:A method and composition for increasing muscle protein synthesis in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at an amino acid derivative including L-carnitine and a nitrogenous organic acid including creatine. In a particular embodiment, the creatine is in an acid resistant capsule delivery form. The ratio of L-carnitine to creatine can be from about 10:1 to about 1:1. The protein building composition can be administered in a monolithic enteric capsule.

专利号:US-2022370392-A1
优先权日:2019-10-16
标 题:Method and Composition for Increasing Muscle Protein Synthesis
发明人：BELLAMINE AOUATEF; GLAB STANISLAW; DURKEE SHANE
权利人:BELLAMINE AOUATEF; CAPSUGEL BELGIUM NV
摘要:A method and composition for increasing muscle protein synthesis in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at an amino acid component including L-carnitine and a nitrogenous organic acid including creatine. In a particular embodiment, the creatine is in a solution with L-carnitine. The ratio of L-carnitine to creatine can be from about 10:1 to about 1:1. The protein building z composition can be administered in a monolithic enteric capsule.

专利号:US-10888571-B2
优先权日:2015-12-18
标 题:Method and composition for increasing muscle protein synthesis and/or functional strength in mammals
发明人：BELLAMINE AOUATEF; ZHIVKOVICH ILYA; FREITAS ULLA
权利人:LONZA CONSUMER HEALTH INC
摘要:A method and composition for preserving muscle mass and function by increasing muscle protein synthesis and/or decreasing muscle protein degradation in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at least two of an essential amino acid, an amino acid derivative, and a nitrogenous organic acid. In a particular embodiment, the protein building composition comprises leucine, L-carnitine, and creatine. The protein building composition can decrease TNF-α and increase mTOR expression in muscle.

专利号:US-11970435-B2
优先权日:2017-05-12
标题:Taste-modified creatine salts, compounds, compositions and uses thereof
发明人：LEBEDYEVA IRYNA; KLUG CHRISTOPHER
权利人:UNIV RES INST INC AUGUSTA
摘要:Provided are embodiments of creatine and creatine ethyl ester (CEE) salts where the anion is an artificial (non-saccharide) taste-modifier. These compounds represent stable white non-hygroscopic solids or semisolids that can readily dissolve in water and buffer solutions. Synthesis of novel creatine salts using environmentally safe solvents such as ethanol resulted in the formation of products in quantitative yields with sodium or potassium chloride as a byproduct. The creatine and creatine alkyl eater derivative salts are stable sweet-tasting compounds that are more palatable to a consumer than creatine or derivatives thereof.