CAS: 52208-23-8; Nimustine Hydrochloride

专利信息

专利号:US-12054512-B2
优先权日:2017-11-10
标 题 :Sting modulator compounds, and methods of making and using
发明人：VYSKOCIL STEPAN; CIAVARRI JEFFREY; CULLIS COURTNEY; ENGLAND DYLAN BRADLEY; GOULD ALEXANDRA E; GREENSPAN PAUL; HU YONGBO; LANGSTON STEVEN; LI GANG; MIZUTANI HIROTAKE; OKANIWA MASANORI
权利人:TAKEDA PHARMACEUTICALS CO
摘要:The present disclosure provides STING modulators/agonists, and methods of synthesis and methods for using for the prophylaxis or treatment of cancer and other STING-related diseases.The present disclosure relates to a compound represented by the Formula (I):wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.

专利号:US-9023384-B2
优先权日:2004-11-02
标题:Liposome and method for injecting substance to cell using this liposome
发明人：MORITA IKUO; AKIYOSHI KAZUNARI; NOMURA SHINICHIRO
权利人:MORITA IKUO; AKIYOSHI KAZUNARI; NOMURA SHINICHIRO; UNIV TOKYO MEDICAL & DENTAL; DAINIPPON PRINTING CO LTD
摘要:It is intended to efficiently inject into a target cell, a substance charged within a liposome. The present inventors have found that connexin synthesized within a liposome is introduced as connexon having a gap junction function into the liposome membrane. Specifically, the liposome according to the present invention is a liposome in which connexon composed of connexin synthesized by an in-vitro protein synthesis system is incorporated in a state of having a gap junction function.

专利号:RU-2085557-C1
优先权日:1991-09-30
标 题:Pyrimidine nucleoside derivatives or their pharmaceutically acceptable salts and method of their synthesis

专利号:US-8791263-B2
优先权日:2010-09-17
标 题 :Cortistatin A analog and use thereof
发明人：KOBAYASHI MOTOMASA; KOTOKU NAOYUKI; ARAI MASAYOSHI; TAMURA SATORU
权利人:KOBAYASHI MOTOMASA; KOTOKU NAOYUKI; ARAI MASAYOSHI; TAMURA SATORU; UNIV OSAKA
摘要:A compound represented by the general formula (M): n n n n n n n n n n n n (wherein R 1 represents a substituted or unsubstituted aromatic heterocyclic group, n R 2 represents a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 3 carbon atoms, OR 3 , N(R 3 ) 2 , C(â•?O)OR 3 or C(â•?O)N(R 3 ) 2 , n R 3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 4 carbon atoms, n R 4 represents a hydrogen atom, an oxygen atom or OR 5 , and n R 5 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, or an acyl group having 1 to 3 carbon atoms); or n a pharmaceutically acceptable salt thereof is a cortistatin A analog which is useful as an active ingredient of medicaments for cancer prevention or treatment in that the analog can be mass-produced by chemical synthesis due to its simple chemical structure and retains the same biological activities as those of cortistatin A.

专利号:CN-104031048-B
优先权日:2014-05-28
标题 :A kind of β-chloroethylnitrosourea compound and its synthesis method and application

专利号:RU-2116306-C1
优先权日:1990-06-15
标 题:Pyrimidine nucleosides, methods of synthesis, pharmaceutical composition