CAS: 50610-34-9; Trisodium,2-Aminoacetate,Carbonate

专利信息

专利号:US-2025049791-A1
优先权日:2023-08-03
标题:Synthesis of MEK7 Inhibitors and methods of Use Thereof
发明人：SCHEIDT KARL A; KIM DALTON ROBERT; ORR MEGHAN JO
权利人:UNIV NORTHWESTERN
摘要:Disclosed herein are 4-phenoxypyrimidine compounds and derivatives thereof for use as inhibitors of mitogen-activated protein kinase 7 (MEK7). The disclosed compounds and pharmaceutical compositions thereof may be used in methods for treating a disease or disorder associated with MEK7 activity, including cell proliferative diseases and disorders associated with MEK7 activity, such as cancer.

专利号:US-11078153-B2
优先权日:2019-04-03
标题:2-difluoro substituted 4-aminocyclopentanecarboxylic acids as inhibitors of gamma-aminobutyric acid aminotransferase and human ornithine aminotransferase
发明人：SILVERMAN RICHARD B
权利人:UNIV NORTHWESTERN
摘要:Disclosed are enantiomerically pure cyclopentane-based compounds that are prepared by a multiple-step synthesis process. The disclosed compounds have been designed to inhibit gamma-aminobutyric acid-amino transferase (GABA-AT) activity and ornithine aminotransferase (OAT) activity. Some of the enantiomerically pure compounds inhibit OAT activity more potently than the racemic compound. The disclosed compounds may be used to selectively inhibit OAT activity, for example, to treat hepatocellular carcinoma and/or used to selected inhibit GABA-AT activity, for example, to treat neurological diseases and disorders.

专利号:AU-2022332910-A1
优先权日:2021-08-23
标 题 :Synthesis and evaluation of novel (4-hydroxyphenyl) substituted carbocycles as potent and selective estrogen receptor beta agonists

专利号:CA-3229664-A1
优先权日:2021-08-23
标 题 :Synthesis and evaluation of novel (4-hydroxyphenyl) substituted carbocycles as potent and selective estrogen receptor beta agonists