CAS: 392-12-1; Indole-3-Pyruvic Acid

该化合物是有机化合物,属于非白衍生物类别,其特征是其结构,包括一个蛋白环和一种丙酸碱;它是在各种植物中发现的自然产生的化合物,以其在助产物生物合成中作为先质的作用而著称,后者是调节生长和发育的基本植物荷尔蒙;IPA通常是白色至白晶状固体,在水和有机溶剂中可溶解,并显示出一个因纯度而异的熔点;该化合物由于在农业和医药中的潜在应用,特别是在植物生长条例和可能的治疗剂方面,因此对研究产生了兴趣;其生物活动包括抗氧化剂特性和对细胞信号路径的潜在影响;与许多有机化合物一样,IPA应当谨慎处理,遵循适当的安全准则,以减少与使用该物质有关的任何风险.

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CAS号73-22-3 L-色氨酸 | CAS号54753-57-0 4-(1'H-indol-3'... | CAS号54-12-6 色氨酸 | CAS号79189-76-7 Tryptophan,N-(c... | CAS号871023-09-5 2-imino-3-(1H-i... | CAS号1912-33-0 吲哚-3-乙酸甲酯 | CAS号153-94-6 D-色氨酸 | CAS号328-50-7 α-酮戊二酸 | CAS号32817-17-7 indol-3-yl-pyru... | CAS号487-89-8 3-吲哚甲醛 | CAS号87-51-4 吲哚-3-乙酸 | CAS号127-17-3 丙酮酸 | CAS号153-94-6 D-色氨酸 | CAS号73-22-3 L-色氨酸 | CAS号832-97-3 DL-3-吲哚乳酸 | CAS号771-50-6 吲哚-3-甲酸 | CAS号879-37-8 3-吲哚乙酰胺 | CAS号3050-37-1 indole-3-glycol... | CAS号150044-68-1 3,4-bis(1H-indo...

合成工艺路线路线简述

    L-色氨酸置于npr1275,Nicotinamide Adenine Dinucleotide体系中,化学反应生成3-(3-吲哚基)-2-氧代丙酸
    参考文献:研究蓝细菌防晒剂 Scytonemin 生物合成的初始步骤
    标题:研究蓝细菌防晒剂 Scytonemin 生物合成的初始步骤
    摘要:蓝藻天然产物 Scytonemin (1) 起到防晒作用,吸收有害的 Uv-A 辐射.使用来自最近确定的基因簇的信息,我们提出了该色素的生物合成途径.我们还报告了参与该途径初始阶段的两种酶 Npr1275 和 Npr1276 的表征.吲哚-3-丙酮酸 (4) 和对羟基苯基丙酮酸 (5) 之间的区域选择性 Acyloin 反应是组装所提出的单体 Scytonemin 前体 (2) 的碳框架的关键步骤.
    Doi:10.1021/ja807192U

    海关参考信息

    专利信息


    专利号:WO-2023198025-A1
    优先权日:2022-04-11
    标题:Synthesis method and synthesis device for organic nitrogen-containing compound
    发明人:LI GUANGQIN; Liao Peisen; XIAN JIAHUI; LI SUISHENG; ZHANG YAWEI
    权利人:UNIV SUN YAT SEN
    摘要:The present invention relates to the field of organic synthesis, specifically to a synthesis method and synthesis device for an organic nitrogen-containing compound. Provided in the present invention is a synthesis method for an organic nitrogen-containing compound. In the method provided in the present invention, a porous carbon material is used as a catalyst, organic nitrogen-containing compounds such as an oxime, an amine, a nitrile and an amino acid are synthesized by means of an electro-catalysis method, byproducts are unlikely to generate, and the method is safe and environmentally friendly. Experiments show that organic nitrogen-containing compounds such as an amino acid, an oxime, an amine and a nitrile are successfully synthesized by using the method of the present invention, and the method has good Faraday efficiency and yield. In the present application, the synthesis of the above organic nitrogen-containing compounds can be realized by using nitrogen oxide waste gas or waste water as a raw material; and by converting the nitrogen oxide waste gas or waste water, the utilization of waste is realized, and the benefits are maximized. Further provided in the present invention is a synthesis device for an organic nitrogen-containing compound, which device is used for solving the defects of high energy consumption, long consumption time, and complex product separation and purification of existing synthesis methods.

    专利号:WO-2008150031-A1
    优先权日:2007-06-08
    标题:Inhibitor of biosynthesis of plant hormone auxin, chemical plant regulator comprising the inhibitor as active ingredient, herbicidal agent, and use thereof
    发明人:SHIMADA YUKIHISA; GODA HIDEKI; TACHIKAWA TOMOE; ISHII TAKAHIRO; SOENO KAZUO; FUJIOKA SHOZO; ASAMI TADAO
    权利人:RIKEN; SHIMADA YUKIHISA; GODA HIDEKI; TACHIKAWA TOMOE; ISHII TAKAHIRO; SOENO KAZUO; FUJIOKA SHOZO; ASAMI TADAO
    摘要:The first object is to provide an inhibitor of the synthesis of endogenous auxin. The second object is to provide a plant growth inhibitor or a herbicidal agent utilizing the auxin biosynthesis inhibitor. Thus, disclosed are: a method for screening a candidate for an auxin biosynthesis inhibitor capable of inhibiting the expression of an auxin-inducible gene, by adding each of candidate compounds for the auxin inhibitor to a plant; a method for selecting a compound capable of actually inhibiting the auxin synthesis in a plant, by adding each of candidate compounds to the plant, disrupting the plant and then measuring the amount of endogenous auxin; and a method for selecting a compound capable of inhibiting the production of indolpyruvic acid in the presence of a tryptophan deaminase and tryptophan which are prepared in advance. More specifically disclosed are: an auxin biosynthesis inhibitor comprising AVG, AOA, AOIBA, L-AOPP or an analogue thereof; and a plant growth regulator or a herbicidal agent comprising the compound as an active ingredient.

    专利号:US-9481898-B2
    优先权日:2010-01-15
    标题 :Electro-autotrophic synthesis of higher alcohols
    发明人:LIAO JAMES C; CHO KWANG MYUNG
    权利人:UNIV CALIFORNIA
    摘要:The disclosure provides a process that converts CO 2 to higher alcohols (e.g. isobutanol) using electricity as the energy source. This process stores electricity (e.g. from solar energy, nuclear energy, and the like) in liquid fuels that can be used as high octane number gasoline substitutes. Instead of deriving reducing power from photosynthesis, this process derives reducing power from electrically generated mediators, either H 2 or formate. H 2 can be derived from electrolysis of water. Formate can be generated by electrochemical reduction of CO 2 . After delivering the reducing power in the cell, formate becomes CO 2 and recycles back. Therefore, the biological CO 2 fixation process can occur in the dark.

    专利号:US-2013288320-A1
    优先权日:2012-04-27
    标题 :Methods and microorganisms for increasing the biological synthesis of difunctional alkanes
    发明人:LAU MAN KIT
    权利人:BIOAMBER INC
    摘要:A method of increasing the production a difunctional alkane in a microorganism that produces a difunctional alkane from alpha-keto acid by increasing the production of homocitrate in the cell relative to a wild-type or parent cell. The production of homocitrate may be obtained by engineering pathways that increase the production of alpha-ketoacid, such as alpha-ketoglutarate.

    专利号:US-9062314-B2
    优先权日:2008-12-12
    标题 :Biological synthesis of difunctional alkanes from carbohydrate feedstocks
    发明人:BAYNES BRIAN M; GEREMIA JOHN MICHAEL
    权利人:CELEXION LLC
    摘要:Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.

    专利号:US-6605430-B1
    优先权日:1998-08-12
    标题 :DNA shuffling of monooxygenase genes for production of industrial chemicals
    发明人:AFFHOLTER JOSEPH A; DAVIS S CHRISTOPHER; SELIFONOV SERGEY A
    权利人:MAXYGEN INC
    摘要:This invention provides improved monoxygenases, dehydrogenases, and transferases that are useful for the biocatalytic synthesis of compounds such as α-hydroxycarboxylic acids, and aryl- and alkyl-hydroxy compounds. The polypeptides provided herein are improved in properties such as regioselectivity, enzymatic activity, stereospecificity, and the like. Methods for obtaining recombinant polynucleotides that encode these improved polypeptides are also provided, as are organisms that express the polypeptides and are thus useful for carrying out said biocatalytic syntheses. Also provided by the invention are methods for increasing said solvent resistance of organisms that are used in the synthetic methods.
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    主要参考文献

    [参考文献]: I P Lapin, Et Al. Anxiolytic Effect Of Indole-3-Pyruvic Acid (Ipa) In Mice. Pharmacol Res. 1993 Sep;28(2):129-34.
    [参考文献]: Reiji Aoki, Et Al. Indole-3-Pyruvic Acid, An Aryl Hydrocarbon Receptor Activator, Suppresses Experimental Colitis In Mice. J Immunol. 2018 Dec 15;201(12):3683-3693.
    [参考文献]: Reiji Aoki, Et Al. Protective Effect Of Indole-3-Pyruvate Against Ultraviolet B-Induced Damage To Cultured Hacat Keratinocytes And The Skin Of Hairless Mice. Plos One. 2014 May 8;9(5):E96804.
    [参考文献]: G B Kulkarni, Et Al. Indole-3-Acetic Acid Biosynthetic Pathway And Aromatic Amino Acid Aminotransferase Activities In Pantoea Dispersa Strain Gpk. Lett Appl Microbiol. 2013 May;56(5):340-7.
    [参考文献]: Joon-Yung Cha, Et Al. A Novel Thiol-Reductase Activity Of Arabidopsis Yuc6 Confers Drought Tolerance Independently Of Auxin Biosynthesis. Nat Commun. 2015 Aug 28:6:8041.

    合成参考文献


    参考文献:10.1007/s00253-011-3468-z
    摘要:Hoshino T. Violacein and related tryptophan metabolites produced by Chromobacterium violaceum: biosynthetic mechanism and pathway for construction of violacein core. Applied Microbiology and Biotechnology. 2011 Jul 22;91(6):1463–75. doi: 10.1007/s00253-011-3468-z.
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