CAS: 36070-75-4; 5-Chloropyrazine-2-Carbonitrile

英文名称5-Chloropyrazine-2-Carbonitrile
中文名称2-氯-5-氰基吡嗪
IUPAC名称5-chloropyrazine-2-carbonitrile
其它别名5-氯-2-氰基吡嗪; 5-Chloropyrazine-2-Carbonitrile
CAS编号36070-75-4
MFCD编号:MFCD09607700
EINECS号:640-607-3
分子式:C5H2ClN3
分子量:139.54
产品CID: 1369714
产品分类有机原料→分子砌块→芳杂环类化合物→吡嗪类化合物

相似结构搜索
InChIKey: GTYRFWMSDBGPTI-UHFFFAOYSA-N
InChI=1S/C5H2ClN3/c6-5-3-8-4(1-7)2-9-5/h2-3H…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数0.0

相似化合物

21279-64-1 36070-80-1 88625-24-5

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别3(经口)
严重眼刺激类别2A
警示词Warning(警告)
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H301 |吞咽会中毒.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xn
安全声明26-36/37
危险类别码20/21/22-36/37/38

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号768-36-5 3-吡嗪羧酰胺 1-氧化物 | CAS号98-96-4 吡嗪酰胺 | CAS号25594-31-4 3-CYANOPYRAZINE... | CAS号21279-64-1 5-氯吡嗪-2-甲酰胺

合成工艺路线路线简述

吡嗪酰胺置于双氧水,三氯氧磷体系中,化学反应生成2-氯-5-氰基吡嗪
参考文献:Reaction Between 2-Amino-2-Deoxy-D-Glucose Derivatives And Sulfite. Synthesis Of 2-(D-Arabino-Tetra-Hydroxybutyl)Pyrazine-5-Sulfonic Acid.
标题:Reaction Between 2-Amino-2-Deoxy-D-Glucose Derivatives And Sulfite. Synthesis Of 2-(D-Arabino-Tetra-Hydroxybutyl)Pyrazine-5-Sulfonic Acid.
摘要:
Doi:10.1271/bbb1961.46.2169

海关参考信息

2926909090-其他腈基化合物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-2023226658-A1
优先权日:2022-05-25
标题:Nitrogen-containing five-membered heterocyclic derivatives as checkpoint kinase 1 inhibitor and uses thereof
发明人：LIU HANLAN; MA JINGJING; HUANG YUNG-JEN; CAI ZHANG; WANG XIAOHUI; YAN ZHIYU; KHAN PASHA M; PANPATIL DAYANAND; PUJALA BRAHMAM; RUAN JUXIN
权利人:SPEROGENIX THERAPEUTICS LTD
摘要:The present disclosure relates generally to nitrogen-containing five-membered heterocyclic derivatives usefulness in treatment of conditions associated with Checkpoint kinase (CHK), particularly more specifically CHK-1 enzymes. Methods of use, compositions, and method of synthesis are also disclosed.