CAS: 280-57-9; 1,4-Diazabicyclo[2.2.2]Octane

相似化合物

54581-69-0 33322-06-4 14968-74-2

上下游产品

CAS号140-31-8 氨基乙基哌嗪 | CAS号67-56-1 甲醇 | CAS号141-43-5 2-氨基乙醇 | CAS号103-76-4 N-羟乙基哌嗪 | CAS号107-15-3 乙二胺 | CAS号124-41-4 甲醇钠 | CAS号112-24-3 三乙烯四胺 | CAS号7483-59-2 3-(1-哌嗪)-1,2-丙二醇 | CAS号108203-98-1 4-butyl-1-aza-4... | CAS号17640-15-2 氰基甲酸甲酯 | CAS号195532-12-8 普拉沙星 | CAS号192723-46-9 benzyl N-(2-chl... | CAS号18503-52-1 4-oxido-1-aza-4... | CAS号93-97-0 苯甲酸酐 | CAS号35367-38-5 氟脲杀 | CAS号51-79-6 氨基甲酸乙酯 | CAS号110-85-0 哌嗪 | CAS号6830-31-5 Piperazine, 1,4...

在 Rh/al2O3,氢气体系中,用 四氢呋喃 用作溶剂,175.0 °C,5.0 Mpa 条件下,以87.6%的收率获得三乙烯二胺
参考文献:一种三乙烯二胺的合成方法
标题:一种三乙烯二胺的合成方法
摘要:本发明涉及一种三乙烯二胺的合成方法,解决了现有生产工艺成本高或原料有一定的危险性,不环保,合成工艺繁琐,产物收率低等技术问题.其包括以下步骤:(1)反应瓶中加入草酸二酯,将哌嗪提前用溶剂溶解后加入,加入催化剂,30~80oc的反应温度下滴加用溶剂溶解的哌嗪,滴加后搅拌1~2小时后过滤,所得滤饼用溶剂洗涤,干燥,得中间产物双氧三乙烯二胺;(2)向高压反应釜内加入步骤(1)制得的双氧三乙烯二胺,加入溶剂至完全溶解,加入催化剂,将釜盖盖紧密封,升温至150~200°C,向高压阀内充入氢气至压力达到2~10Mpa,反应过程中持续充入氢气保持压力,得三乙烯二胺粗品;(3)后处理得最终产物三乙烯二胺.本发明应用于三乙烯二胺的合成.

专利信息

专利号:US-8822702-B2
优先权日:2002-12-20
标 题 :Synthesis of amines and intermediates for the synthesis thereof
发明人：BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL
权利人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL; BASF SE
摘要:The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, n nor especially of amides of the formula II,n n nwherein the symbols have the meanings given in the specification, as well as other intermediates and compounds useful in the synthesis of tryptamines and other substances mentioned in the title. The synthesis methods and intermediates are useful in the synthesis of pharmaceuticals.

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:WO-2025053792-A1
优先权日:2023-09-06
标题:Collective synthesis of phantomolin family through total synthesis of the sesquiterpene lactone molephantin
发明人：CHIBA SHUNSUKE; PATOURET REMI HENRI LOUIS; LI HOI YEUNG; LAI SOAK KUAN
权利人:UNIV NANYANG TECH
摘要:Disclosed herein are processes to generate an intermediate in the total synthesis of (+)- molephantin or a derivative thereof, and a total synthesis of (+)-molephantin or a derivative thereof. Also disclosed herein are methods of forming a compound of formula XIV and of forming a compound of formula XV, wherein compound of formula XIV and compound of formula XV are as defined in the description.

专利号:US-7928223-B2
优先权日:2008-06-20
标题:Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：LERESTIF JEAN-MICHEL; LECOUVE JEAN-PIERRE; BRIGOT DANIEL
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n n n n n n n n n n Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-8273790-B2
优先权日:2005-01-14
标 题:Exo-selective synthesis of himbacine analogs
发明人：THIRUVENGADAM TIRUVETTIPURAM K; SUDHAKAR ANANTHA; LIM NGIAP KIE; KWOK DAW-IONG; WU GEORGE G; WANG TAO; HUANG MINGSHENG; GREEN MICHAEL D
权利人:THIRUVENGADAM TIRUVETTIPURAM K; SUDHAKAR ANANTHA; LIM NGIAP KIE; KWOK DAW-IONG; WU GEORGE G; WANG TAO; HUANG MINGSHENG; GREEN MICHAEL D; SCHERING CORP
摘要:This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人：LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.