CAS: 2417-72-3; Methyl 4-(Bromomethyl)Benzoate

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CAS号99-75-2 对甲基苯甲酸甲酯 | CAS号186581-53-3 重氮甲烷 | CAS号6232-88-8 对溴甲基苯甲酸 | CAS号67-56-1 甲醇 | CAS号6908-41-4 4-(羟基甲基)苯甲酸甲酯 | CAS号52780-16-2 4-溴甲基苯甲酰氯 | CAS号94-36-0 过氧化苯甲酰 | CAS号1571-08-0 对甲酰基苯甲酸甲酯 | CAS号108-90-7 氯苯 | CAS号558-13-4 四溴化碳 | CAS号110654-40-5 4-(氨磺酰基甲基)苯甲酸甲酯 | CAS号351335-29-0 4-((2-甲酰基苯氧基)甲基... | CAS号52787-14-1 4-甲酸甲酯苯乙酸甲酯 | CAS号31719-76-3 4-苯氧基甲基苯甲酸 | CAS号150630-10-7 methyl 4-[[(4-m... | CAS号14295-52-4 4-((二乙氧基磷酰基)甲基)苯甲酸甲酯 | CAS号142979-85-9 methyl 4-[[4-[(... | CAS号147969-86-6 4-((1-(叔丁氧基羰基)哌... | CAS号444667-11-2 4-(羧基甲基)-3-硝基苯甲酸 | CAS号91271-60-2 [4-(吡咯烷-1-甲基)苯基]甲醇

对甲基苯甲酸甲酯置于溴体系中,用 苯 用作溶剂,化学反应 2.0H,以86%的收率获得4-溴甲基苯甲酸甲酯
参考文献:一种新型高亲水性笼养基团的合成和光物理表征
标题:一种新型高亲水性笼养基团的合成和光物理表征
摘要:邻硝基苄基保护的生物活性化合物是生物物理学中的有用工具,允许以高时间和空间精度控制生物活性化合物的光释放.因此,可以比以前更详细地研究生物过程,例如神经递质-受体相互作用和许多其他过程.在这方面,这些笼状化合物已成为非常有用的工具.然而,在某些情况下,它们的生物特性(笼状化合物不应与生物系统相互作用),它们的光化学特性(光释放的量子产率和动力学)和它们的物理特性(高亲水性)并不令人满意.为了解决最后一个问题,我们研究了增加基于邻硝基苄基部分的笼状化合物亲水性的方法.这里,我们报告了一种新的笼状 D-天冬氨酸衍生物的合成以及光化学和生物表征,与之前报道的衍生物相比,该衍生物具有极大的改善的亲水性,并且具有令人满意的光物理特性.因此,具有这种改进的邻硝基苄基的笼状化合物可能代表了用于不同类型生物物理研究的有价值的新工具.(© Wiley-Vch Verlag Gmbh,69451 Weinheim
Doi:10.1002/1099-0690(200203)2002:6<1037::Aid-Ejoc1037>3.0.Co;2-4

专利信息

专利号:US-2025026768-A1
优先权日:2023-06-30
标题:Method for the synthesis of axially chiral organoboron compounds
发明人：PING YIFAN; CHE CHI-MING
权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.

专利号:US-12129222-B2
优先权日:2016-08-11
标题:Production of bitter principle derivatives
发明人：WYRWA RALF; RODE CLAUDIA; SEEMANN THOMAS; MEINEL LORENZ; RITZER JENNIFER; SCHNABELRAUCH MATTHIAS
权利人:UNIV WUERZBURG J MAXIMILIANS; JULIUS MAXIMILIANS UNIV
摘要:It is an object of the present invention to introduce carboxylic acid-functionalities suitable for coupling into the denatonium structure by means of simple synthesis, namely the synthesis of bitter principle derivatives based on the denatonium structure according to formula 1:For example, according to the invention, lidocaine derivatives may be reacted with carboxylated benzyl halogenides. The carboxylated denatonium derivatives of the present invention are especially applied in medicine, biology, medical engineering as well as cosmetics, the pharmaceutical, chemical, and foodstuff industry.

专利号:US-2024336559-A1
优先权日:2021-10-06
标 题 :Anti-fungals compounds targeting the synthesis of fungal sphingolipids
发明人：OJIMA IWAO; HARANAHALLI KRUPANANDAN; DEL POETA MAURIZIO; GARG ASHNA
权利人:UNIV NEW YORK STATE RES FOUND
摘要:The present invention provides a compound having the structure: n n n n n n n n n n n n wherein n R 3 , R 4 , R 5 , R 6 , and R 7 are each independently, H, halogen, CN, —CF 3 , —OCF 3 , —NO 2 , alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, —OH, —OAc, —OR 13 , —COR 13 , —CH 2 OR 13 , —SH, —SR 13 , —SO 2 R 13 , —NH 2 , —NHR 13 , —NR 14 R 15 , —NHCOR 12 , or —CONR 14 R 15 ; n R 9 , R 10 , R 11 , and R 12 are each independently, H, CN, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, —OAc, —COR 13 , —SH, —SR 13 , —SO 2 R 13 , —NH 2 , —NHR 13 , —NR 14 R 15 , —NHCOR 12 , or —CONR 14 R 15 ;n wherein each occurrence of R 13 is independently alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R 14 is independently —H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R 15 is independently —H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, n n wherein when R 14 is methyl, R 15 is not methyl; n wherein at least one of R 9 , R 10 , R 11 , and R 12 is not H; n wherein at least one of R 3 , R 4 , R 5 , R 6 , and R 7 is not H.

专利号:US-5932743-A
优先权日:1997-08-21
标 题:Methods for the solid phase synthesis of substituted indole compounds
发明人：COLLINI MICHAEL D; ELLINGBOE JOHN W
权利人:AMERICAN HOME PROD
摘要:The present invention relates to novel substituted indole compounds of formula (I) having pharmacological activity, to processes for their preparation, to solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

专利号:US-8461298-B2
优先权日:2004-11-01
标 题:Compositions and methods for modification of biomolecules
发明人：BERTOZZI CAROLYN R; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL
权利人:BERTOZZI CAROLYN R; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL; UNIV CALIFORNIA
摘要:The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

专利号:WO-2021255429-A1
优先权日:2020-06-15
标题:Process for preparing n,n-dimethyl-4-((6-oxopyrimidin-1(6h)-yl)methyl)benzamide from 4-((6-oxopyrimidin-1(6h)-yl)methyl)benzoic acid, and crystalline forms of the benzamide
发明人：RAMSDEN NIGEL; FOX DAVID JOHN; TOMLINSON JAMES MICHAEL
权利人:Z FACTOR LTD
摘要:The invention includes a process for the synthesis of N,N-dimethyl-4-((6-oxopyrimidin-1(6H)- yl)methyl)benzamide and 4-((6-oxopyrimidin-1(6H)-yl)methyl)benzoic acid, a process for 5 synthesising crystalline forms of N,N-dimethyl-4-((6-oxopyrimidin-1(6H)- yl)methyl)benzamide, and crystalline forms of N,N-dimethyl-4-((6-oxopyrimidin-1(6H)- yl)methyl)benzamide.