CAS: 23680-84-4; 2-Chloro-4-Amino-6,7-Dimethoxyquinazoline

上下游产品

CAS号27631-29-4 2,4-二氯-6,7-二甲氧基喹唑啉 | CAS号192869-38-8 4-Amino-2-chlor... | CAS号2150-38-1 3,4-二甲氧基苯甲酸甲酯 | CAS号26791-93-5 4,5-二甲氧基-2-硝基苯甲酸甲酯 | CAS号28888-44-0 6,7-二甲氧基-2,4-喹唑啉二酮 | CAS号26759-46-6 2-氨基-4,5-二甲氧基苯甲酸甲酯 | CAS号4998-07-6 4,5-二甲氧基-2-硝基苯甲酸 | CAS号4959-60-8 4,5-二甲氧基-2-硝基苯甲酰胺 | CAS号5004-88-6 2-氨基-4,5-二甲氧基苯甲酰胺 | CAS号81403-68-1 盐酸阿夫唑嗪 | CAS号81403-80-7 阿夫唑嗪 | CAS号84050-22-6 2-哌嗪基-4-氨基-6,7-... | CAS号63590-64-7 特拉唑嗪 | CAS号76362-28-2 N-(4-氨基-6,7-二甲氧... | CAS号74191-85-8 多沙唑嗪 | CAS号70918-01-3 盐酸多沙唑嗪 | CAS号60547-97-9 2-(1-哌嗪基)-4-氨基-... | CAS号19216-56-9 哌唑嗪 | CAS号65189-49-3 N-[3-[(4-amino-...

2,4-二氯-6,7-二甲氧基喹唑啉置于ammonium Hydroxide体系中,用 四氢呋喃 用作溶剂,化学反应生成2-氯-4-氨基-6,7-二甲氧基喹唑啉
参考文献:激活transport-P所需的prazosin分子的分子特征.
标题:激活transport-P所需的prazosin分子的分子特征.
摘要:已经合成了哌唑嗪的紧密相关的结构类似物,并测试了其对transport-P的抑制和激活,以鉴定似乎对于激活transport-P必不可少的prazosin分子的结构特征.到目前为止,所有测试的化合物都没有比哌唑嗪具有更高的活性.结果表明,哌唑嗪的结构似乎对激活非常特异.已发现仅喹唑啉可活化,并且6,7-二甲氧基和4-氨基的存在似乎至关重要.
Doi:10.1016/j.Bmc.2008.06.037

专利信息

专利号:US-6080860-A
优先权日:1992-08-31
标 题:Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
发明人：KARIMIAN KHASHAYAR; MURTHY KESHAVA; HALL DARREN
权利人:BRANTFORD CHEMICALSS INC
摘要:Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediates suitable for use in such methods of synthesis are taught.

专利号:WO-2009001369-A1
优先权日:2007-06-22
标 题 :An improved process for the preparation of alfuzosin hydrochloride
发明人：DEO KESHAV; DESAI SANJAY; RATHOD DHIRAJ MOHANSINH; PARIKH CHIRAG CHANDRAKANT; PATEL RIPALKUMAR KANTIBHAI
权利人:ALEMBIC LTD; DEO KESHAV; DESAI SANJAY; RATHOD DHIRAJ MOHANSINH; PARIKH CHIRAG CHANDRAKANT; PATEL RIPALKUMAR KANTIBHAI
摘要:The present invention relates to an improved process for the preparation of Alfuzosin hydrochloride of formula (I) comprising a step of reacting compound of formula (IV) with compound of formula (V) in presence of aprotic solvent to obtain compound of formula (III) which is a useful intermediate for synthesis of Alfuzosin hydrochloride of formula (I).

专利号:WO-2008084493-A3
优先权日:2007-01-09
标 题 :A novel process for the preparation of 2-halo-4-aminoquinazolines
发明人：BHOBE AJIT MADHUKAR; DAMLE SUBHASH VISHWANATH; ADHVARYU RUSHI DRUPADBHAI
权利人:UNICHEM LAB LTD; BHOBE AJIT MADHUKAR; DAMLE SUBHASH VISHWANATH; ADHVARYU RUSHI DRUPADBHAI
摘要:2-Halo-4-aminoquinazolines are produced by a one-step process involving intramolecular cyclization of appropriately substituted formamide derivatives in the presence of phosphorous oxyhalides. Exemplary of the process is the intramolecular cyclization of 3,4-dimethoxy-6-cyanoaniline-1-yl formamide in the presence of phosphorous oxychloride to 2-chloro-4-amino-6,7-dimethoxyquinazoline. These chemical compounds are utilized as intermediates in the preparation of some of the important antihypertensive agents e.g. 2-chloro-4-amino-6,7-dimethoxyquinazolines is used for the synthesis of alfuzosin hydrochloride.

专利号:US-2008039473-A1
优先权日:2006-08-08
标题:Preparation and utility of substituted quinazoline compounds with alpha-adrenergic blocking effects
发明人：GANT THOMAS G; SARSHAR SEPEHR
权利人:AUSPEX PHARMACEUTICALS INC
摘要:The present disclosure is directed to modulators of alpha-adrenergic receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the use of such compounds for the treatment and/or management of hypertension, cardiac failure, prostatitis, and benign prostatic hyperplasia, and any other condition in which it is beneficial to modulate an alpha-adrenergic receptor.

专利号:WO-9405628-A1
优先权日:1992-08-31
标 题 :Synthesis of 2-substituted quinazoline compounds (such as terazosin) and meobentine and bethanidine and intermediates therefor

专利号:EP-0656885-A1
优先权日:1992-08-31
标 题 :Synthesis of 2-substituted quinazoline compounds (such as terazosin) and meobentine and bethanidine and intermediates therefor