CAS: 21913-98-4; 3'-Methoxydaidzein

主要参考文献

参考标题:Synthesis Of Various Kinds Of Isoflavones, Isoflavanes, And Biphenyl-Ketones And Their 1,1-Diphenyl-2-Picrylhydrazyl Radical-Scavenging Activities
作者:Hideyuki Goto,Yoshiyasu Terao,Shuji Akai
摘要:Forty-Eight Kinds Of Isoflavones (8), Thirty-One Isoflavanes (9), And Forty-Seven Biphenyl-Ketones (10, 10′) Were Synthesized From Eleven Kinds Of Substituted Phenols (11) And Six Phenylacetic Acids (12). Among Them, Seventy-Five Compounds Are New. The Radical Scavenging Activities Of These Compounds Were Evaluated Using 1,1-Diphenyl-2-Picrylhydrazyl (Dpph) At Ph 6.0. We Found That Thirty-Nine Out Of Forty-Three Compounds Having A Catechol Moiety On Either The A- Or The B-Ring Exhibited A High Activity (Ed50=12-54 μm) Similar To That Of Catechin. In These Cases, The Remaining Part Of Their Structure Seemed To Have Little Effect On Their Activity. Many 6- Or 8-Hydroxyisoflavanes (9E-I) And Their Biphenyl-Ketone Derivatives (10E-H) Also Showed A High Activity (Ed50=<50 μm), While All Of Their Corresponding Isoflavones (8E-I) Were Not Active At All. The 7-Hydroxyisoflavanes Having Either An Additional Hydroxyl Group At The C5-Position (9D) Or A Methoxy Group At The C6-Position (9J) Presented A High Activity (Ed50=26-32 μm). This Study Suggests That Natural Isoflavones Have The Possibilities Of Exhibiting Antioxidant Activities Through The Hydroxylation At The C6-, C8-, Or C3′-Position Or The Formation Of The Isoflavanes (9) And/or The Biphenyl-Ketone Derivatives (10′) By Metabolism Or Biotransformation.

合成参考文献

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参考文献:10.1007/s10593-023-03160-8
摘要:Tang L, Chen L, Jia Z, Zheng H, Li Z, Yin X. Synthesis and neuroprotective activity of a (–)-cytisine-isoflavone conjugate. Chem Heterocycl Comp. 2023 Feb;59(1-2):41–7. doi: 10.1007/s10593-023-03160-8.
参考文献:10.1021/np100339u
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参考文献:10.1016/j.jchromb.2012.01.008
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