CAS: 194851-16-6; 7-Bromoquinazolin-4(3H)-One

上下游产品

7-Bromo-1-(4-Methoxy-Benzyl)-1H-Quinazolin-4-One 832114-32-6

📜2-氨基-4-溴苯甲酸甲酯置于indium(III) Chloride体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 0.83H,反应生成7-溴喹唑啉-4(3H)-酮
参考文献:角噻唑并[5,4-F ]和[4,5-H ]喹唑啉的新型合成,其线性噻唑并[4,5-G ]和[5,4-G ]喹唑啉类似物的制备
标题:角噻唑并[5,4-F ]和[4,5-H ]喹唑啉的新型合成,其线性噻唑并[4,5-G ]和[5,4-G ]喹唑啉类似物的制备
摘要:9-氧代8,9-二氢噻唑[5,4-F ]喹唑啉-2-腈(1)或6-氧代6,7-二氢噻唑[4,5-H ]喹唑啉-2-腈(2)的合成)进行了重新研究,目的是改变与喹唑啉4-One部分相连的噻唑环的位置,以便合成两个新颖的线性三环式8-氧代-7,8-二氢噻唑并[4,5-G ]喹唑啉-2-甲腈(3)和8-氧代7,8-二氢噻唑并[5,4-G ]喹唑啉-2-甲腈(4).本文描述的途径为获得有效的生物活性杂环化合物文库提供了各种替代和转化途径.
Doi:10.1016/j.Tet.2013.02.066

专利信息

专利号:US-8772301-B2
优先权日:2009-12-18
标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.