CAS: 193000-39-4; 5-((7-(Benzyloxy)Quinazolin-4-yl)Amino)-4-Fluoro-2-Methylphenol Hydrochloride

主要参考文献

1: Im S, Song MH, Elangovan M, Woo KM, Park WJ. The matricellular protein CCN5 prevents anti-VEGF drug-induced epithelial-mesenchymal transition of retinal pigment epithelium. Sci Rep. 2024 Jun 17;14(1):13920. doi: 10.1038/s41598-024-63565-z.
2: Fan LJ, Kan HM, Chen XT, Sun YY, Chen LP, Shen W. Vascular endothelial growth factor-A/vascular endothelial growth factor2 signaling in spinal neurons contributes to bone cancer pain. Mol Pain. 2022 Jan-Dec;18:17448069221075891. doi: 10.1177/17448069221075891.
3: Deissler HL, Stutzer JN, Lang GK, Grisanti S, Lang GE, Ranjbar M. VEGF receptor 2 inhibitor nintedanib completely reverts VEGF-A165-induced disturbances of barriers formed by retinal endothelial cells or long-term cultivated ARPE-19 cells. Exp Eye Res. 2020 May;194:108004. doi: 10.1016/j.exer.2020.108004. Epub 2020 Mar 14. 131(5):1125-1147. doi: 10.1097/ALN.0000000000002916. 116(3):708-720. doi: 10.1093/cvr/cvz159. 316(5):H1076-H1090. doi: 10.1152/ajpheart.00685.2018. Epub 2019 Feb 15.

合成参考文献

参考文献:10.1016/j.bmc.2023.117561
摘要:Takarada JE, Cunha MR, Almeida VM, Vasconcelos SNS, Santiago AS, Godoi PH, Salmazo A, Ramos PZ, Fala AM, de Souza LR, Da Silva IEP, Bengtson MH, Massirer KB, Couñago RM. Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors. Bioorg Med Chem. 2024 Jan 15;98():117561. doi: 10.1016/j.bmc.2023.117561.