CAS: 17763-80-3; 4-Nitrophenyl Trifluoromethanesulfonate

上下游产品

Phenyl triflate 4-nitro-phenol trifluoromethylsulfonic anhydride trifluorormethanesulfonic acid 1-(4-nitro-phenyl)-pyrrolidine 1-(4-nitrophenyl)piperidine 1-morpholino-4-nitrobenzene 4-°Ctylaniline

📜2-碘苯基三氟甲磺酸酯置于三氟化硼乙醚,Caesium Carbonate,间氯过氧苯甲酸体系中,用 二氯甲烷,乙腈 用作溶剂,化学反应 13.92H,反应生成4-硝基苯酚三氟甲基磺酸酯
参考文献:Diaryliodonium盐的分子内芳基迁移:获得邻碘二芳基醚的途径
标题:Diaryliodonium盐的分子内芳基迁移:获得邻碘二芳基醚的途径
摘要:通过使用邻位的三氟甲磺酸取代的二芳基碘鎓盐,开发了一种通过分子内芳基迁移合成邻碘二芳基醚的新方法.反应条件温和,底物范围广.机械学的见解表明了磺酰基定向的亲核芳族取代途径.另外,产物邻碘二芳基醚可作为通用合成子,已通过数个偶联反应得到证明.此外,通过这种芳基迁移步骤合成了3-碘-1-甲状腺素(3-T 1)衍生物的有用的甲状腺素类似物.
Doi:10.1002/anie.201806405

专利信息

专利号:US-10155772-B2
优先权日:2010-07-08
标题:Process for the synthesis of substituted morphinans
发明人：DUNCAN SCOTT
权利人:ALKERMES PHARMA IRELAND LTD
摘要:The invention further relates to a process for the synthesis of 3-carboxamide substituted morphinans where a 3-cyano substituted 6-oxo substituted morphinan is reacted with a 1,3-diol.

专利号:US-9227948-B2
优先权日:2012-06-19
标题:Process for the preparation of 2-substituted-2-(6-(substituted)-7-methylbenzo[D][1,3]dioxol-4-yl)acetic acid derivatives
发明人：MUDDASANI PULLA REDDY; CHINTALAPUDI MANIKUMAR; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD
摘要:Present invention relates to an improved and commercial process for the preparation of 2-sustituted-2-(6-(substituted)-7-methylbenzo[d][1,3]dioxol-4-yl)acetic acid derivatives of formula-I the above Formula I, XII, XIII, XV, wherein R 1 is a O-protecting group such as methoxymethyl, ethoxymethyl, trialkylsilyl, arylmethyl, tetrahydropyran-2-yl, allyl; X is hydroxyl, halogen, mesylate, triflate, tosylate, acetate; Y is oxygen atom, NH or sulfur atom; R 2 is C 1 -C 6 alkyl. 2,4-Dihydroxy-3-methylbenzaldehyde is selectively protected at C-4 position in the form of an ether compound of formula-XII, oxidized the aldehyde function to get the diol of formula-XIII, and condensed with ethyl glyoxalate under Casiraghi reaction conditions to get the compound of formula-XV. Compound of formula-XV is converted to compound of formula-I by conventional chemistry. Compounds of formula-I are key intermediates in the synthesis of ecteinascidines like trabectedin.

专利号:US-12421204-B2
优先权日:2019-11-19
标 题 :Process for preparing chroman compounds
发明人：KAMBOJ RAJENDER KUMAR; KOCHUMALAYIL SHAJI GEORGE; VENUGOPAL SPINVIN; PADIYA KAMLESH JYOTINDRA; KAMALAKANNAN PRABAKARAN; NAIK KUMAR RAM; INGAWALE SACHIN SUBHASH; RAJESH BHAVANI SHANKAR; POWAR RAJENDRA GANPATI
权利人:LUPIN LTD
摘要:A process for manufacturing substituted chroman compounds in an economically scalable manner, without the use of pyrophoric reagents. Also disclosed herein are chroman compound synthesis routes that do not include column chromatography purification steps. The disclosure also relates to the intermediates used in the synthesis. In particular, the disclosure relates to the synthesis of the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts thereof.

专利号:US-12344592-B2
优先权日:2020-01-17
标题 :Methods, processes and intermediates for preparing chroman compounds
发明人：KAMBOJ RAJENDER KUMAR; PADIYA KAMLESH JYOTINDRA; PRABAKARAN KAMALAKANNAN; NAIK KUMAR RAM; RAJESH BHAVANI SHANKAR; RAJENDRA GANPATI POWAR; SACHIN SUBHASH INGAWALE; AMIT DATTATRAY KARCHE; SANTOSHKUMAR SHANKAR DANGE; SITARAM RAMBHAU BARVE
权利人:LUPIN LTD
摘要:This disclosure describes an economical and scalable method and process to synthesize the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts therefor. Uses of said intermediates for synthesis of compounds which may be intermediates to the synthesis of 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid are also described herein.

专利号:US-2018334464-A1
优先权日:2010-07-08
标 题 :Process for the Synthesis of Substituted Morphinans

专利号:US-7999090-B2
优先权日:2000-07-07
标 题:Fungal cell wall synthesis gene
发明人：TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO
权利人:EISAI R&D MAN CO LTD
摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.