CAS: 166896-74-8; 17B-(Tert-Butylcarbamoyl)-4-Aza-5A-Androsten-3-One

该化合物是一种合成类固醇衍生物,其特征是17个位置有异丁基碳酸盐基组,氮原子取代固态脊柱4个位置的碳.这种复合物显示出类固醇的典型特性,包括可能与代谢作用或代谢途径的调节等生物活动发生相互作用和受体受体可能受到影响. 异丁基碳酸盐酸酯会加强其亲脂性,有可能影响其生物利用率和药性.此外,4a类替代会改变化合物的电子特性和胃结构,从而影响其与生物目标的结合性和选择性.作为合成类,可以在研究环境中探索类固醇激素功能或开发具有特定药理特征的治疗剂.应观测到安全性和谨慎性,作为生物活动的潜在化学毒性.

英文名称17B-(Tert-Butylcarbamoyl)-4-Aza-5A-Androsten-3-One
中文名称N-叔丁基-3-酮-4-氮杂-5α-雄甾烯-17β-酰胺
其它别名3-酮-4-氮杂-5-雄烯-17β-叔丁酰胺; Finasteride Impurity
CAS编号166896-74-8
MFCD编号:MFCD09038716
分子式:C23H36N2O2
分子量:372.54
产品CID: 844814
产品分类有机原料→分子砌块→手性化合物→手性砌块

相似结构搜索
InChIKey: BIPCVLBBDHLXSX-XDLZGBJCSA-N
1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h9,14-17H,6-8,10-13H2,1-5H3,(H,24,26)(H,2…
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数1.0

相似化合物

103335-54-2 104214-18-8 98319-24-5

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

上下游产品

CAS号302-97-6 3-氧代-雄甾-4-烯-17β-羧酸 | CAS号131267-80-6 N-皮丁基-4-雄烯-3-酮-... | CAS号57072-90-9 3-oxoandrost-4-... | CAS号98319-26-7 非那雄胺 | CAS号98319-24-5 二氢波斯卡

合成工艺路线路线简述

3-Oxoandrost-4-Ene-17β-Carboxylic Acid Chloride置于乙酸铵,Potassium Permanganate,Sodium Periodate,Sodium Carbonate体系中,用水,溶剂黄146,叔丁醇用作溶剂,化学反应 5.0H,反应生成N-叔丁基-3-酮-4-氮杂-5A-雄甾烯-17B-酰胺
参考文献:Synthesis Of N-Substituted 3-Oxo-17B-Carboxamide-4-Aza-5A-Androstanes And The Tautomerism Of 3-Oxo-4-Aza-5-Androstenes
标题:Synthesis Of N-Substituted 3-Oxo-17B-Carboxamide-4-Aza-5A-Androstanes And The Tautomerism Of 3-Oxo-4-Aza-5-Androstenes
摘要:An N-Aryl-3-Oxo-4-Aza-5 Alpha-Androst-1-Ene-17 Beta-Carboxamide And Three N-Aryl Or Alkyl Substituted 17 Alpha-Hydroxy-3-Oxo-4-Aza-5 Alpha-Androstane-17 Beta-Carboxamides Were Synthesized As Antiandrogen Candidates From 3-Oxoandrost-4-Ene-17 Beta-Carboxylic Acid And Androst-4-Ene-3,17-Dione Respectively. The Chemo-And Stereoselective Reduction Of 3-Oxo-4-Aza-5-Ene Intermediates With Formic Acid And Their Tautomerism In A Solution Of Chloroform And Methanol Were Described.
Doi:10.3987/com-97-S(N)35