邻硝基苯乙酮置于sodium Hydroxide,Sodium Tetrahydroborate,三氯化铝,溴体系中,用 四氢呋喃,乙醚,乙醇,水 用作溶剂,化学反应生成2-(2-硝基苯基)乙醇 参考文献:Antibacterial Benzisoxazolones. An Unusual Rearrangement Product From O-Nitrostyrene Oxide En Route To The Photolabile Carbonyl Protecting Group,(O-Nitrophenyl)Ethylene Glycol 标题:Antibacterial Benzisoxazolones. An Unusual Rearrangement Product From O-Nitrostyrene Oxide En Route To The Photolabile Carbonyl Protecting Group,(O-Nitrophenyl)Ethylene Glycol 摘要: Doi:10.1021/jo00177A010
专利号:US-2005101763-A1 优先权日:2003-09-30 标 题 :Synthesis of photolabile 2-(2-nitrophenyl)propyloxycarbonyl protected amino acids 发明人:DELISI CHARLES P; LAURSEN RICHARD A; BHUSHAN KUMAR R 权利人:UNIV BOSTON 摘要:The 2-(2-nitrophenyl)propyloxycarbonyl (NPPOC) group has been introduced as a photolabile amino protecting group for amino acids to be used as building blocks in photolithographic solid-phase peptide synthesis. NPPOC-protected amino acids were found to be cleaved in the presence of UV light about twice as fast as the corresponding o-nitroveratryloxycarbonyl (NVOC)-protected amino acids. The protected amino acids are of particular use in the synthesis of peptide arrays.
专利号:US-9428524-B2 优先权日:2010-05-25 标 题:Synthetic process for the manufacture of ecteinascidin compounds 发明人:MARTIN LÓPEZ MA JESÚS; FRANCESCH SOLLOSO ANDRÉS; CUEVAS MARCHANTE MARIA DEL CARMEN 权利人:MARTIN LÓPEZ MA JESÚS; FRANCESCH SOLLOSO ANDRÉS; CUEVAS MARCHANTE MARIA DEL CARMEN; PHARMA MAR SA 摘要:This invention relates to compounds of formula II: wherein R 1 , R 2 , Prot SH , and Prot NH are as defined, to processes for the synthesis of ecteinascidins of formula I from compounds of formula II, and to processes for the synthesis of compounds of formula II.
专利号:US-3978140-A 优先权日:1974-09-23 标题 :Process for the preparation of carbinols 发明人:LANE CLINTON FISHER; MYATT HAL LESLIE 权利人:ALDRICH BORANES INC 摘要:Organic compounds containing a carboxylic acid or carboxylic acid anhydride group are reduced when contacted with an alkali metal borohydride and a boron trihalide in a liquid medium in which diborane is soluble in the form of a labile borane adduct. Hydrolysis of the reaction mixture then provides a useful synthesis of the corresponding carbinols. n The alkali metal borohydride-boron trihalide reagent may either be preformed and reacted subsequently with an organic compound containing a carboxylic acid or anhydride group, or the alkali metal borohydride-boron trihalide reagent may be produced in the presence of an organic compound containing a carboxylic acid or anhydride group. This development makes it possible to synthesize a wide variety of carbinols which are valuable and useful intermediates in organic synthesis.
专利号:US-4886887-A 优先权日:1985-11-08 标 题 :Process for the preparation of indolines 发明人:AEBLI BEAT M; GREMMELMAIER CLAUDE 权利人:CIBA GEIGY CORP 摘要:Indolines of the formula ##STR1## wherein R 1 is hydrogen or C 1 -C 4 alkyl and each of R 2 and R 3 independently of the other is hydrogen, C 1 -C 4 alkyl or phenyl, are prepared by cyclodehydrating a 2-(2'-aminophenyl)ethanol of formula ##STR2## wherein R 1 , R 2 and R 3 are as defined above, at 150°-350° C. in the presence of an amorphous aluminum silicate. n The indolines of the above formula are useful intermediates for the synthesis of plant protective agents.
专利号:US-9163038-B2 优先权日:2012-03-19 标 题:Process for synthesis of chiral 3-substituted tetrahydroquinoline derivatives 发明人:RAWAT VARUN; BOOPATHI SENTHIL KUMAR; SUDALAI ARUMUGAM 权利人:COUNCIL SCIENT IND RES 摘要:The present invention relates to novel and concise process for the construction of chiral 3-substituted tetrahyroquinoline derivatives based on proline catalyzed asymmetric α-functionalization of aldehyde, followed by in situ reductive cyclization of nitro group under catalytic hydrogenation condition with high optical purities. Further the invention relates to conversion of derived chiral 3-substituted tetrahydroquinoline derivatives into therapeutic agents namely (−)-sumanirole (96% ee) and 1-[(S)-3-(di-methylamino)-3,4-dihydro-6,7-dimethoxy-quinolin-1(2H)-yl]propanone[(S)-903] (92% ee).
专利号:US-2004053999-A1 优先权日:1997-09-17 标题 :Novel compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
摘要:National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. 摘要:Joule, J. A., Science of Synthesis, (2001) 10, 415. 摘要:Stankevič, M.; Pietrusiewicz, K. M., Science of Synthesis, (2009) 42, 292.