CAS: 143192-31-8; Fmoc-N-(3-Boc-Aminopropyl)-Glycine

该化合物是常用于浸泡合成和研究的化学化合物,其特点是保护氨基酸结构,氨基酸结构,FMOC(9-氟基甲基乙氧碳基)作为保护该矿的团体,允许不受矿功能干扰的选择性反应.BOC(乙基-丁基氧碳基)组保护3-氨基丙基链的氨基组,加强分子在合成过程中的稳定性和再活性.该化合物的特点是其相对较高的分子重量和具体的功能组,有利于固相聚聚聚的聚反应.其溶性通常存在于有机溶剂中,适合各种实验室应用.FMOC和BOC组的存在可以逐步地进行脱保,从而能够按顺序组装peptids.

英文名称Fmoc-N-(3-Boc-Aminopropyl)-Glycine
中文名称N-[3-[[(1,1-二甲基乙氧基)羰基]氨基]丙基]-N-[(9H-芴-9-基甲氧基)羰基]-甘氨酸
IUPAC名称N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-(3-((tert-butoxycarbonyl)amino)propyl)glycine
其它别名2-[(3-{[(Tert-Butoxy)Carbonyl]Amino}Propyl)({[(9H-Fluoren-9-yl)Methoxy]Carbonyl})Amino]Acetic Acid; 2-[9H-Fluoren-9-Ylmethoxycarbonyl-[3-[(2-Methylpropan-2-yl)Oxycarbonylamino]Propyl]Amino]Acetic Acid; Fmoc-N-(3-Boc-Aminopropyl)-Gly-Oh; Fmoc-Norn(Boc)-Oh; Fmoc-N-(3-Boc-Aminopropyl)-Glycine; Glycine,N- 3- (1,1-Dimethylethoxy)Carbonyl Amino Propyl -N- (9H-Fluoren-9-Ylmethoxy)Carbonyl -; N-[3-(Boc-Amino)Propyl]-N-Fmoc-Glycine; N-α-(9-Fluorenylmethoxycarbonyl)-N-α-{[3-(T-Butoxycarbonyl)Amino]Propyl}Glycine
CAS编号143192-31-8
MFCD编号:MFCD04112688
分子式:C25H30N2O6分子量:454.52
产品CID: 659944
产品分类有机原料 → 羧酸类化合物及衍生物

相似结构搜索
InChIKey: IMAPLGVUJDLQCK-UHFFFAOYSA-N
InChI=1S/C25H30N2O6/c1-25(2,3)33-23(30)26-13-8-14-27(15-22(28)29)24(31)32-16-21-19-11-6-4-9-17(19)18-10-5-7-12-20(18)21/h4-7,9-12,21H,8,13-16H2,1-3H3,(H,26,30)(H,28,29)
计算化学: 氢键受体数6.0氢键供体数2.0可旋转键数11.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P305+P351+P338

上下游产品

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide [3-(t-butyloxycarbonylamino)-1-propylamino]acetate tert-butyl dicarbonatedi-tert-butyl dicarbonate N-B°C-1,3-diaminopropane

合成工艺路线路线简述

合成目标产物 Fmoc-N-(3-Boc-Aminopropyl)-Glycine 主要起始原料 N-(9-Fluorenylmethoxycarbonyloxy)Succinimide And N-[3-(Boc-Amino)Propyl]-Glycine
(文献来源)合成步骤主要原料 N-(9-Fluorenylmethoxycarbonyloxy)Succinimide 和 N-[3-(Boc-Amino)Propyl]-Glycine

📜叔-丁基(3-(苯甲基氨基)丙基)氨基甲酯置于palladium On Activated Charcoal 氢气,三乙胺,N,N-二异丙基乙胺体系中,用甲醇,N,N-二甲基甲酰胺,乙腈用作溶剂,25.0 °C,413.69 Kpa 条件下,反应 11.5H,反应生成N-[3-[[(1,1-二甲基乙氧基)羰基]氨基]丙基]-N-[(9H-芴-9-基甲氧基)羰基]-甘氨酸
参考文献:Building Units For N-Backbone Cyclic Peptides. 3. Synthesis Of Protected Nα-(ω-Aminoalkyl)Amino Acids And Nα-(ω-Carboxyalkyl)Amino Acids
标题:Building Units For N-Backbone Cyclic Peptides. 3. Synthesis Of Protected Nα-(ω-Aminoalkyl)Amino Acids And Nα-(ω-Carboxyalkyl)Amino Acids
摘要:An Improved Synthesis Of A Family Of Amino Acids That Contain Omega-Aminoalkyl Groups And Of A New Family Containing Omega-Carboxyalkyl Groups Linked To The Alpha-Amine Is Described. The Synthesis Was Performed By Alkylation Of Suitably Monoprotected Alkylenediamines And Protected Omega-Amino Acids With Triflates Of Alpha-Hydroxy Acid Esters. The Reaction Proceeded With Inversion Of Configuration Yielding Optically Pure Products. The N-Alpha-(Omega-Aminoalkyl)Amino Acids And N-Alpha-(Omega-Carboxyalkyl)Amino Acids Were Orthogonally Protected To Allow Their Incorporation Into Peptides By Solid-Phase Peptide Synthesis (Spps) Methodology.
Doi:10.1021/jo961580E