专利号:US-10252972-B2 优先权日:2015-06-30 标 题 :Synthesis of long-chain unsaturated fatty acid by chemical reaction of carbon chain extension 发明人:BAMBA NAOMICHI; MISAWA YOSHIHISA; TABATA HIROSHI; SHIMIZU YOSHIO 权利人:BIZEN CHEMICAL CO LTD 摘要:A method of chemically extending a carbon chain of an unsaturated fatty acid for conversion into a different unsaturated fatty acid has been reported. The present invention shortens reaction steps of conventional methods, and completes a carbon chain extending reaction in a shorter time. The present invention provides a method of extending a carbon chain of an unsaturated fatty acid by two carbons, comprising steps of four stages including a short-path conversion reaction of an unsaturated fatty chain obtained from an unsaturated fatty acid into a malonic ester derivative, and heating of the malonic ester derivative to reflux in a lower fatty acid solution. The method of the present invention can complete a carbon chain extending reaction in a shorter time.
专利号:US-8884051-B2 优先权日:2010-10-20 标题:Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent 发明人:MALOFSKY BERNARD M; MALOFSKY ADAM G; DEY TANMOY; SULLIVAN JEFFREY M; CHEN YANGBIN; WOJCIAK STANLEY C; COCKREM MICHAEL C 权利人:MALOFSKY BERNARD M; MALOFSKY ADAM G; DEY TANMOY; SULLIVAN JEFFREY M; CHEN YANGBIN; WOJCIAK STANLEY C; COCKREM MICHAEL C; BIOFORMIX INC 摘要:The present invention provides a method of making a methylene malonate monomer that includes the steps of reacting a malonic acid ester with a source of formaldehyde optionally in the presence of an acidic or basic catalyst and optionally in the presence of an acidic or non-acidic solvent to form reaction complex. The reaction is optionally performed in the presence of or contacted with an energy transfer means such as a heat transfer agent, a heat transfer surface, a source of radiation or a laser such that reaction complex is substantially vaporized to produce a vapor phase comprising methylene malonate monomer which may be isolated. The present invention further provides methylene malonate monomers prepared by the method of the invention, as well as compositions and products formed from the methylene malonate monomers, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).
专利号:WO-2012078147-A1 优先权日:2010-12-08 标 题:A process for the preparation of intermediates useful in the production of aliskiren 发明人:BHANU MANJUNATH NARAYAN; NAIK SAMIR; THOMAS REJOY 权利人:WATSON LAB INC; BHANU MANJUNATH NARAYAN; NAIK SAMIR; THOMAS REJOY 摘要:A process for preparing 4-[(2R)-2-X-methyl)-3-methylbutyl]-1 -methoxy-2-3(3- methoxypropoxy)-benzene wherein X is a leaving group and use of this compound in the synthesis of aliskiren.
专利号:US-9440991-B2 优先权日:2013-12-23 标 题:Synthesis of an antiviral compound 发明人:CAGULADA AMY; CHAN JOHANN; CHAN LINA; COLBY DENISE A; KARKI KAPIL KUMAR; KATO DARRYL; KEATON KATIE ANN; KONDAPALLY SUDHA; LEVINS CHRIS; LITTKE ADAM; MARTINEZ RUBEN; PCION DOMINIKA; REYNOLDS TROY; ROSS BRUCE; SANGI MICHAEL; SCHRIER ADAM J; SENG PAMELA; SIEGEL DUSTIN; SHAPIRO NATHAN; TANG DONALD; TAYLOR JAMES G; TRIPP JONATHAN; WALTMAN ANDREW W; YU LAWRENCE 权利人:GILEAD SCIENCES INC 摘要:The present disclosure provides processes for the preparation of a compound of formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
专利号:JP-H11349536-A 优先权日:1987-03-05 标题:Method for synthesizing monoesters or diesters of 9,10-endoethano-9,10-dihydroanthracene-11,11-dicarboxylic acid, novel monoesters or diesters obtained by this synthesis method, and their proportioned or irregular methylidene marone -Application to synthesis of
专利号:US-2017210756-A1 优先权日:2013-12-23 标题 :Synthesis of an antiviral compound
[参考文献]: H Jinno, Et Al. Hepatotoxicity Of Diisopropyl Ester Of Malonic Acid And Chloromalonic Acids, Disinfection By-Products Of The Fungicide Isoprothiolane. Arch Toxicol. 1997;71(9):550-5.
合成参考文献
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